Suicidal ideation during adolescence: The roles of aggregate genetic liability for suicide attempts and negative life events in the past year.
Suicidal ideation during adolescence: The roles of aggregate genetic liability for suicide attempts and negative life events in the past year.
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DOI：
10.1111/jcpp.13653
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发表时间：
2022-10
影响因子：
7.6
通讯作者：
Edwards, Alexis C.
中科院分区：
文献类型：
--
作者：
Lannoy, Severine;Mars, Becky;Heron, Jon;Edwards, Alexis C.
自杀想法和行为（STB）是青少年的一个中心公共卫生问题。以往的研究强调，青少年时期难以科普负性生活事件是STB的一个危险因素。家族和遗传的责任也被记录下来解释STB风险。然而，对总体遗传责任及其与负面生活事件的可能相互作用知之甚少。此外，需要了解这些因素如何不同地影响男孩和女孩的STB。我们评估了17岁时的自杀意念，并在2，571名青少年样本中研究了总遗传倾向，负性生活事件及其相互作用的作用。总的遗传易感性是使用多基因得分（PGS）自杀企图。在过去的一年中评估了负性生活事件，包括父母离婚和住院，朋友和亲戚的死亡，欺凌，失败相关事件和药物参与。我们进行了按性别分层的单变量和多变量一般线性模型，并在随后的模型中评估了PGS和负性生活事件之间的相互作用。分析表明，男孩的自杀意念与未能实现重要目标（估计值= 0.198），欺凌（估计值= 0.285），吸毒（估计值= 0.325）和父母死亡（估计值= 0.923）有关。在女孩中，总遗传倾向（估计值= 0.041）和负面生活事件（学校失败[估计值= 0.120]，未能实现重要的事情[估计值= 0.279]，吸毒[估计值= 0.395]和欺凌[估计值= 0.472]）与自杀意念相关。互动分析表明，PGS互动与药物使用和失败在学校，虽然这将需要额外的支持。这些研究结果代表了对青少年STB的基本理解的重大贡献，建议在青春期监测负面生活事件的影响，以更好地预防自杀风险。遗传责任对女孩也很重要，可能影响她们应对环境威胁的方式。
Suicidal thoughts and behaviors (STB) constitute a central public health concern in adolescence. Previous studies emphasized the difficulty to cope with negative life events during adolescence as a risk factor for STB. Familial and genetic liability has also been documented to explain STB risk. Nevertheless, less is known about aggregate genetic liability and its possible interaction with negative life events. Moreover, information is needed to understand how these factors differently affect STB in boys and girls. We evaluated suicidal ideation at 17 years old and examined the role of aggregate genetic liability, negative life events, and their interaction in a sample of 2,571 adolescents. Aggregate genetic liability was measured using a polygenic score (PGS) for suicide attempts. Negative life events were assessed in the past year and included parental divorce and hospitalizations, death of friends and relatives, bullying, failure‐related events, and involvement with drugs. We conducted univariable and multivariable general linear models stratified by sex and evaluated the interactions between PGS and negative life events in subsequent models. Analyses showed that suicidal ideation in boys is associated with failure to achieve something important (estimate = 0.198), bullying (estimate = 0.285), drug use (estimate = 0.325), and parental death (estimate = 0.923). In girls, both aggregate genetic liability (estimate = 0.041) and negative life events (failure at school [estimate = 0.120], failure to achieve something important [estimate = 0.279], drug use [estimate = 0.395], and bullying [estimate = 0.472]) were associated with suicidal ideation. Interaction analyses suggested that PGS interacted with drug use and failures at school, though this would need additional support. These findings represent significant contributions to the fundamental understanding of STB in adolescence, suggesting to monitor the impact of negative life events during adolescence to better prevent suicide risk. Genetic liability is also of importance in girls and might influence the way they respond to environmental threats.
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DOI：
10.1176/appi.ajp.2020.19101025
发表时间：
2020-10-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Docherty AR;Shabalin AA;DiBlasi E;Monson E;Mullins N;Adkins DE;Bacanu SA;Bakian AV;Crowell S;Chen D;Darlington TM;Callor WB;Christensen ED;Gray D;Keeshin B;Klein M;Anderson JS;Jerominski L;Hayward C;Porteous DJ;McIntosh A;Li Q;Coon H
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Coon H
DOI：
10.1002/ajmg.b.32010
发表时间：
2012-01
影响因子：
2.8
作者：
Althoff, Robert R.;Hudziak, James J.;Willemsen, Gonneke;Hudziak, Vicenta;Bartels, Meike;Boomsma, Dorret I.
通讯作者：
Boomsma, Dorret I.
影响因子：
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影响因子：
4.3
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