Genetic and environmental contributions to self-reported thoughts of self-harm and suicide.
Genetic and environmental contributions to self-reported thoughts of self-harm and suicide.
复制标题
DOI：
10.1002/ajmg.b.32010
复制
发表时间：
2012-01
影响因子：
2.8
通讯作者：
Boomsma, Dorret I.
中科院分区：
文献类型：
--
作者：
Althoff, Robert R.;Hudziak, James J.;Willemsen, Gonneke;Hudziak, Vicenta;Bartels, Meike;Boomsma, Dorret I.
自残和自杀行为的想法被认为受到遗传和环境的影响。分子遗传学研究开始解决可能涉及哪些基因以及男性和女性是否表达不同基因的问题。我们研究了一个大的一般人群双胞胎样本，包括男性和女性同性和异性双胞胎的自我伤害和自杀行为的想法。在这项研究中，关于自我报告的自残和自杀想法的数据来自荷兰双胞胎登记处的6265对11-90岁的双胞胎（11,008人）的自我报告问卷（贝克抑郁量表和青年或成人自我报告表）。责任阈值模型进行了比较，包括性别和年龄（线性和二次）的影响。模型进行了比较，使用简约的措施，以计算最简单的模型的数据。添加剂的遗传和独特的环境贡献的模型适合男性和女性的数据。没有质的性别差异，但男女之间的相对贡献不同。女性（0.74，95% CI 0.65 - 0.81）的遗传度高于男性（0.45，95% CI 0.28 - 0.61）。剩余的方差由个体所特有的环境影响来解释。这些结果表明，添加剂的遗传因素的贡献自我报告的想法自我伤害和自杀，并支持分子遗传和个人特定的环境风险因素的继续研究。
Thoughts of self-harm and suicidal behavior are thought to be influenced by both genetics and environment. Molecular genetic studies are beginning to address the question of which genes may be involved and whether different genes may be expressed in men and women. We examined thoughts of self-harm and suicidal behavior in a large general population twin sample including male and female same- and opposite-sex twins. In this study, data on self-reported thoughts of self-harm and suicide were obtained from self-report questionnaires (Beck Depression Inventory and Youth or Adult Self Report forms) in 6265 twin pairs (11,008 individuals) aged 11–90 (62% female) from the Netherlands Twin Registry. Liability threshold models were compared including sex and age (linear and quadratic) effects. Models were compared using measures of parsimony to calculate the simplest model to the data. A model with additive genetic and unique environmental contributions fitted the data for both males and females. There were no qualitative sex differences, but the relative contributions differed between men and women. Heritability was higher in women (0.74, 95% CI 0.65 – 0.81) than men (0.45, 95% CI 0.28 – 0.61). The remaining variance was accounted for by environmental influence unique to an individual. These results suggest contributions from additive genetic factors to self-reported thoughts of self-harm and suicide and support the continued study of both molecular genetic and individual-specific environmental risk factors.
登录
查看更多内容
DOI：
10.1002/ajmg.b.31044
发表时间：
2010-04-01
影响因子：
2.8
作者：
Coventry, William L.;James, Michael R.;Wray, Naomi R.
通讯作者：
Wray, Naomi R.
影响因子：
7.8
作者：
Mann, J. J.;Currier, D. M.
通讯作者：
Currier, D. M.
影响因子：
0.9
作者：
Courtet, P;Jollant, F;Malafosse, A
通讯作者：
Malafosse, A
影响因子：
6.9
作者：
Distel, M. A.;Middeldorp, C. M.;Boomsma, D. I.
通讯作者：
Boomsma, D. I.
DOI：
10.1097/00004583-200111000-00010
发表时间：
2001-11-01
影响因子：
13.3
作者：
Glowinski, AL;Bucholz, KK;Heath, AC
通讯作者：
Heath, AC