Alterations in a cartilage matrix glycoprotein in canine osteoarthritis.
Alterations in a cartilage matrix glycoprotein in canine osteoarthritis.
复制标题
犬骨关节炎中软骨基质糖蛋白的变化。
DOI：
10.1002/art.1780291211
复制
发表时间：
1986
影响因子：
--
通讯作者：
Fife,RS
中科院分区：
文献类型：
--
作者：
Fife,RS
A number of biochemical abnormalities have been described in osteoarthritic (OA) cartilage, but little study has been devoted to changes in the noncollagenous, nonproteoglycan proteins of cartilage in this condition. Using a canine model of OA produced by transection of the anterior cruciate ligament of the knee, we have demonstrated that distinct alterations occur in a 550,000‐dalton cartilage matrix glycoprotein in OA canine cartilage. This protein is a major protein constituent of normal articular cartilage. Fragments which are immunologically cross‐reactive with the 550,000‐dalton protein were more abundant in OA cartilage than in normal articular cartilage. Immunofluorescence studies revealed that staining with specific antiserum to the protein was absent in OA cartilage. This was the only noncollagenous, nonproteoglycan protein noted to undergo significant changes in this model of OA.
登录
查看更多内容
人骨关节炎软骨中的胶原酶和胶原蛋白溶解活性。
影响因子：
--
作者：
Pelletier,JP;Martel-Pelletier,J;Howell,DS;Ghandur-Mnaymneh,L;Enis,JE;WoessnerJr,JF
通讯作者：
WoessnerJr,JF
正常和骨关节炎关节软骨中纤连蛋白的合成。
DOI：
10.1016/0304-4165(84)90093-x
发表时间：
1984
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Wurster,NB;Lust,G
通讯作者：
Lust,G
DOI：
10.1016/0304-4165(84)90370-2
发表时间：
1984-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
FIFE, RS;BRANDT, KD
通讯作者：
BRANDT, KD
正常软骨和关节炎软骨的糖胺聚糖。
影响因子：
15.9
作者：
H. Mankin;L. Lippiello
通讯作者：
L. Lippiello
来自正常和骨关节炎软骨的人类关节软骨连接蛋白的表征。
影响因子：
27.4
作者：
J. Ryu;And CHRISTINE A. TOWLE;Benjamin V. Treadwell
通讯作者：
Benjamin V. Treadwell