Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging.
Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging.
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DOI：
10.3389/fcell.2021.635340
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发表时间：
2021
影响因子：
5.5
通讯作者：
Chuong CM
中科院分区：
文献类型：
--
作者：
Harn HI;Chen CC;Wang SP;Lei M;Chuong CM
在老化过程中，皮肤经历结构和组成的变化。皮肤老化表型的发生是由于基因组/表观基因组，细胞因子/细胞粘附，细胞分布/细胞外基质（ECM）等的累积变化。在这里，我们回顾数据表明，组织力学也在皮肤老化中发挥作用。虽然小鼠和人类皮肤有一些相似之处，但它们的皮肤结构在某些方面有所不同。然而，由于现有的实验数据，我们使用了最近在有毛小鼠皮肤中的研究。皮肤在其附属物和附属物间区域中遭受变化。老年人表现出皱纹和疏松的真皮层，更有可能遭受伤口和浅表擦伤，愈合不良。他们也有皮肤附属物的数量减少。虽然休止期在老化的小鼠皮肤中延长，但如果移植到年轻的皮肤环境中，毛囊干细胞可以恢复活力进入生长期。我们强调了最近对表皮和老化的人类皮肤进行的单细胞分析，这些分析确定了新的基底细胞亚群，这些亚群在受伤时会发生变化。这可能是由于基底膜硬度的改变，这将改变老化皮肤中的组织力学，导致改变的稳态动力学。我们认为细胞外基质（ECM）可能作为多层衰老相关信号通路的化学机械整合剂发挥关键作用，决定了衰老表型中生态位微环境的组织机械景观。我们展示了失败的化学机械信号导致皮肤衰老过程中稳态恶化的例子，并提出了潜在的治疗策略，以指导未来的研究，以延缓衰老过程。
During aging, the skin undergoes changes in architecture and composition. Skin aging phenotypes occur due to accumulated changes in the genome/epigenome, cytokine/cell adhesion, cell distribution/extracellular matrix (ECM), etc. Here we review data suggesting that tissue mechanics also plays a role in skin aging. While mouse and human skin share some similarities, their skin architectures differ in some respects. However, we use recent research in haired murine skin because of the available experimental data. Skin suffers from changes in both its appendages and inter-appendage regions. The elderly exhibit wrinkles and loose dermis and are more likely to suffer from wounds and superficial abrasions with poor healing. They also have a reduction in the number of skin appendages. While telogen is prolonged in aging murine skin, hair follicle stem cells can be rejuvenated to enter anagen if transplanted to a young skin environment. We highlight recent single-cell analyses performed on epidermis and aging human skin which identified new basal cell subpopulations that shift in response to wounding. This may be due to alterations of basement membrane stiffness which would change tissue mechanics in aging skin, leading to altered homeostatic dynamics. We propose that the extracellular matrix (ECM) may play a key role as a chemo-mechanical integrator of the multi-layered senescence-associated signaling pathways, dictating the tissue mechanical landscape of niche microenvironments in aging phenotypes. We show examples where failed chemo-mechanical signaling leads to deteriorating homeostasis during skin aging and suggest potential therapeutic strategies to guide future research to delay the aging processes.
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影响因子：
64.8
作者：
Fiore VF;Krajnc M;Quiroz FG;Levorse J;Pasolli HA;Shvartsman SY;Fuchs E
通讯作者：
Fuchs E
影响因子：
64.5
作者：
Fujiwara H;Ferreira M;Donati G;Marciano DK;Linton JM;Sato Y;Hartner A;Sekiguchi K;Reichardt LF;Watt FM
通讯作者：
Watt FM
影响因子：
5.6
作者：
Gentile P;Cole JP;Cole MA;Garcovich S;Bielli A;Scioli MG;Orlandi A;Insalaco C;Cervelli V
通讯作者：
Cervelli V
影响因子：
8
作者：
Essayem, S;Kovacic-Milivojevic, B;Ilic, D
通讯作者：
Ilic, D
器官水平群体感应指导毛发干细胞群的再生
影响因子：
64.5
作者：
Chen CC;Wang L;Plikus MV;Jiang TX;Murray PJ;Ramos R;Guerrero-Juarez CF;Hughes MW;Lee OK;Shi S;Widelitz RB;Lander AD;Chuong CM
通讯作者：
Chuong CM