Organ-level quorum sensing directs regeneration in hair stem cell populations.
Organ-level quorum sensing directs regeneration in hair stem cell populations.
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器官水平群体感应指导毛发干细胞群的再生
DOI：
10.1016/j.cell.2015.02.016
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发表时间：
2015-04-09
期刊：
影响因子：
64.5
通讯作者：
Chuong CM
中科院分区：
文献类型：
--
作者：
Chen CC;Wang L;Plikus MV;Jiang TX;Murray PJ;Ramos R;Guerrero-Juarez CF;Hughes MW;Lee OK;Shi S;Widelitz RB;Lander AD;Chuong CM
协调的器官行为是对环境刺激的有效反应的关键。通过研究毛囊再生对脱毛的反应，我们证明了器官水平的群体感应允许对皮肤损伤的协调反应。以不同的密度去除毛发会导致相邻未拔掉的静止毛发再生多达5倍，表明集体决策过程的激活。通过数据建模，估计群体信号的范围在1毫米左右，比扩散分子信号的预期范围要大。分子和遗传分析揭示了一个两步机制，其中CCL2从受伤的头发中释放导致分泌TNF-α的巨噬细胞的募集，这些巨噬细胞积聚并向拔毛和未拔毛的毛囊发出信号。通过将免疫反应与再生相结合，这种机制允许皮肤对痛苦做出预测反应，忽略轻微损伤，同时通过干细胞的全面协同激活来应对更严重的损伤。
Coordinated organ behavior is crucial for an effective response to environmental stimuli. By studying regeneration of hair follicles in response to patterned hair removal, we demonstrate that organ-level quorum sensing allows coordinated responses to skin injury. Removing hair at different densities leads to a regeneration of up to 5 times more neighboring, unplucked resting hairs, indicating activation of a collective decision-making process. Through data modeling, the range of the quorum signal was estimated to be on the order of 1 mm, greater than expected for a diffusible molecular cue. Molecular and genetic analysis uncovered a two-step mechanism, where release of CCL2 from injured hairs leads to recruitment of TNF-α secreting macrophages, which accumulate and signal to both plucked and unplucked follicles. By coupling immune response with regeneration, this mechanism allows skin to respond predictively to distress, disregarding mild injury, while meeting stronger injury with full-scale cooperative activation of stem cells.
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影响因子：
21.3
作者：
通讯作者：
--
影响因子：
4.3
作者：
Murray PJ;Maini PK;Plikus MV;Chuong CM;Baker RE
通讯作者：
Baker RE
影响因子：
30.5
作者：
Nagao, Keisuke;Kobayashi, Tetsuro;Moro, Kazuyo;Ohyama, Manabu;Adachi, Takeya;Kitashima, Daniela Y.;Ueha, Satoshi;Horiuchi, Keisuke;Tanizaki, Hideaki;Kabashima, Kenji;Kubo, Akiharu;Cho, Young-hun;Clausen, Bjorn E.;Matsushima, Kouji;Suematsu, Makoto;Furtado, Glaucia C.;Lira, Sergio A.;Farber, Joshua M.;Udey, Mark C.;Amagai, Masayuki
通讯作者：
Amagai, Masayuki
影响因子：
6.5
作者：
Paus, R;van der Veen, C;Hofmann, U
通讯作者：
Hofmann, U
ASK1依赖性募集和巨噬细胞的激活会引起皮肤伤口的头发生长。
影响因子：
7.8
作者：
Osaka, Nao;Takahashi, Takumi;Murakami, Shiori;Matsuzawa, Atsushi;Noguchi, Takuya;Fujiwara, Takeshi;Aburatani, Hiroyuki;Moriyama, Keiji;Takeda, Kohsuke;Ichijo, Hidenori
通讯作者：
Ichijo, Hidenori