Expression of Lewis y antigen and integrin αv, β3 in ovarian cancer and their relationship with chemotherapeutic drug resistance.
Expression of Lewis y antigen and integrin αv, β3 in ovarian cancer and their relationship with chemotherapeutic drug resistance.
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卵巢癌中路易斯Y抗原和整联蛋白αV，β3的表达及其与化学耐药性的关系。
DOI：
10.1186/1756-9966-32-36
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发表时间：
2013-06-01
期刊：
影响因子：
--
通讯作者：
Lin B
中科院分区：
文献类型：
--
作者：
Gao J;Hu Z;Liu D;Liu J;Liu C;Hou R;Gao S;Zhang D;Zhang S;Lin B
本研究探讨Lewis y抗原、整合素αv、β3在上皮性卵巢癌组织中的表达。我们进一步评估它们的表达与卵巢癌化疗耐药之间的关系及其可能的临床意义。纳入92例符合纳入标准、随访资料完整的卵巢癌患者组织，分为化疗耐药组和化疗敏感组。使用免疫组织化学和双标记免疫荧光方法评估石蜡切片中Lewis y抗原和整合素αv、β3的表达和关系。采用多因素logistic回归分析探讨卵巢癌患者年龄、临床分期、分化程度、组织学亚型、Lewis y抗原与整合素αv、β3表达的关系。耐药组Lewis y抗原和整合素αv的表达率显着高于敏感组（p <0.05）。多变量分析显示Lewis y抗原、整合素αv的表达和卵巢癌的临床分期是独立的、耐药相关的危险因素。 Lewis y抗原与整合素αv、β3的表达量呈正相关。 Lewis y抗原、整合素αv、β3与卵巢癌之间存在密切相关性。 Lewis y抗原作为整合素αv、β3的重要组成部分，可以通过某种信号通路影响肿瘤细胞的生物学行为。 Lewis y抗原、整合素αv的表达和卵巢癌的临床分期都是独立的、与耐药相关的危险因素。
This study investigates the expression of Lewis y antigen, integrin αv, β3 in epithelial ovarian cancer tissues. We further evaluate the relationship between their expression and chemotherapy resistance of ovarian cancer and its possible clinical significance. Tissues of 92 patients with ovarian cancer meeting the inclusion criteria with complete follow-up data were enrolled and divided into chemotherapy resistant group and sensitive group. The expression and relationship of Lewis y antigen and integrin αv, β3 are assessed in paraffin sections using immunohistochemistry and double-labeling immunofluorescence method. Multivariate logistic regression analysis was used to investigate the relationship between age, clinical stage, differentiation, histologic subtype, Lewis y antigen and integrin αv, β3 expression in ovarian cancer patients. The expression rates of Lewis y antigen and integrin αv in the resistant group, significantly higher than the rates found in the sensitive group (p <0.05). Multivariate analysis showed that the expression of Lewis y antigen, integrin αv and ovarian cancer’s clinical stage were independent, drug resistance-related risk factors. The expression levels of Lewis y antigen and integrin αv, β3 were positively correlated with each other. A close correlation between Lewis y antigen, integrin αv, β3 and ovarian cancer was observed. Lewis y antigen can influence the biological behavior of a tumor cell as an important composition of integrin αv, β3 by some signal pathway. And the expression of Lewis y antigen, integrin αv and ovarian cancer’s clinical stage are both independent, drug resistance-related risk factors.
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影响因子：
5.6
作者：
Wang Y;Liu J;Lin B;Wang C;Li Q;Liu S;Yan L;Zhang S;Iwamori M
通讯作者：
Iwamori M
影响因子：
20.3
作者：
Damiano, JS;Cress, AE;Dalton, WS
通讯作者：
Dalton, WS
DOI：
10.1111/igc.0b013e3181ea7ecb
发表时间：
2010-12-01
影响因子：
4.8
作者：
Li, Quanrong;Liu, Shuice;Zhang, Shulan
通讯作者：
Zhang, Shulan
影响因子：
4.8
作者：
Zhao, Yanyang;Itoh, Satsuki;Gu, Jianguo
通讯作者：
Gu, Jianguo
Lewis Y 抗原表达增强，卵巢癌 RMG-1 细胞对多西紫杉醇的耐药性增加
影响因子：
5.6
作者：
Zhang F;Liu J;Lin B;Liu Q;Zhao Y;Zhu L;Hao Y;Zhang S;Iwamori M
通讯作者：
Iwamori M