Study on the expression and clinical significances of lewis y antigen and integrin αv, β3 in epithelial ovarian tumors.
Study on the expression and clinical significances of lewis y antigen and integrin αv, β3 in epithelial ovarian tumors.
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DOI：
10.3390/ijms12063409
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发表时间：
2011
影响因子：
5.6
通讯作者：
Iwamori M
中科院分区：
文献类型：
--
作者：
Wang Y;Liu J;Lin B;Wang C;Li Q;Liu S;Yan L;Zhang S;Iwamori M
检测刘易斯y抗原和整合素αv、β3在卵巢上皮性肿瘤中的表达及临床意义，探讨刘易斯y抗原与整合素αv、β3表达的相关性。采用免疫组化方法检测95例上皮性卵巢癌、37例交界性肿瘤、20例良性肿瘤和20例正常卵巢组织中刘易斯y抗原和整合素αv、β3的表达，分析刘易斯y抗原与整合素的关系及与卵巢癌临床病理参数的关系。应用免疫荧光双标记技术检测卵巢癌组织中刘易斯y抗原与整合素αv、β3表达的相关性。上皮性卵巢肿瘤中刘易斯y抗原表达率为81.05%，显著高于交界性卵巢肿瘤（51.53%）（P < 0.05）、良性卵巢肿瘤（25%）（P < 0.01）和正常卵巢组织（0）（P < 0.01）。整合素αv、β3在卵巢恶性上皮性肿瘤中的表达率分别为78.95%和82.11%，明显高于交界性肿瘤卵巢良性病变组分别为10.00%，15.00%（均P <0.01），正常卵巢组分别为5%，15%（均P < 0.01）。刘易斯y和整合素αv、β3与卵巢癌细胞的盆腔和腹腔扩散和转移有关，提示这两种分子介导了肿瘤转移的促进作用。
To detect the expression and clinical significances of Lewis y antigen and integrin αv, β3 in epithelial ovarian tumors, and to explore the expression correlation between Lewis y antigen and integrin αv, β3. Immunohistochemical staining was performed in 95 cases of epithelial ovarian cancer, 37 cases of borderline tumors, 20 cases of benign tumors, and 20 cases of normal ovarian tissue, for the detection of Lewis y antigen and integrin αv, β3 expressions, and to analyze the relationship between Lewis y antigen and integrin, and the relationship between clinical and pathological parameters of ovarian cancer. In addition, immunofluorescence double labeling was utilized to detect the expression correlation between Lewis y antigen and integrin αv, β3 in ovarian cancer. In epithelial ovarian tumors, the expression rate of Lewis y antigen was 81.05%, significantly higher than that of borderline (51.53%) (P < 0.05) and benign (25%) (P < 0.01) tumors, and normal ovarian tissues (0) (P < 0.01). The expression rate of integrin αv, β3 in malignant epithelial ovarian tumors was 78.95% and 82.11%, respectively, significantly higher than that of the borderline (45.94%, 40.54%) (both P < 0.05), benign group (10.00%, 15.00%) (both P < 0.01) and normal ovary group (5%, 15%) (both P < 0.01). Lewis y and integrins αv, β3 are relevant to pelvic and abdominal diffusion and metastasis of ovarian cancer cells, suggesting that these two molecules mediate a boosting function for tumor metastasis.
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影响因子：
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作者：
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通讯作者：
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