Highly effective liquid and solid phase extraction methods to concentrate radioiodine isotopes for radioiodination chemistry.
Highly effective liquid and solid phase extraction methods to concentrate radioiodine isotopes for radioiodination chemistry.
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DOI：
10.1002/jlcr.3994
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发表时间：
2022-08
影响因子：
1.8
通讯作者：
Yan, Ran
中科院分区：
文献类型：
--
作者：
Davis, Christopher;Li, Chun;Nie, Ruirui;Guzzardi, Norman;Dworakowska, Barbara;Sadasivam, Pragalath;Maher, John;Aboagye, Eric O.;Lu, Zhi;Yan, Ran
放射性碘同位素在放射性药物中起着关键作用。大规模生产多患者剂量的放射性碘化核药物需要高浓度的放射性碘。我们证明四丁基氯化铵和甲基三辛基氯化铵是有效的相转移试剂，可以从相应的商业水溶液中浓缩碘-124，碘-125和碘-131。在任一相转移试剂存在下，所得浓缩放射性碘不会妨碍铜（II）介导的一锅法三组分点击化学中放射性碘水溶液的化学反应性，以产生放射性碘化碘三唑。大规模生产多患者剂量的放射性碘化核药物需要高浓度的放射性碘。我们证明了四丁基氯化铵和甲基三辛基氯化铵是有效的相转移试剂，可以从相应的商业水溶液中浓缩碘-124，碘-125和碘-131。在任一相转移试剂存在下，所得浓缩放射性碘不会妨碍铜（II）介导的一锅法三组分点击化学中放射性碘水溶液的化学反应性，以产生放射性碘化碘三唑。
Radioactive iodine isotopes play a pivotal role in radiopharmaceuticals. Large‐scale production of multi‐patient dose of radioiodinated nuclear medicines requires high concentration of radioiodine. We demonstrate that tetrabutylammonium chloride and methyltrioctylamonium chloride are effective phase transfer reagents to concentrate iodide‐124, iodide‐125 and iodide‐131 from the corresponding commercial water solutions. The resulting concentrated radioiodide, in the presence of either phase transfer reagent, does not hamper the chemical reactivity of aqueous radioiodide in the copper (II)‐mediated one‐pot three‐component click chemistry to produce radioiodinated iodotriazoles. Large‐scale production of multipatient dose of radioiodinated nuclear medicines requires high concentration of radioiodine. We demonstrate that tetrabutylammonium chloride and methyltrioctylamonium chloride are effective phase transfer reagents to concentrate iodide‐124, iodide‐125, and iodide‐131 from the corresponding commercial water solutions. The resulting concentrated radioiodide, in the presence of either phase transfer reagent, does not hamper the chemical reactivity of aqueous radioiodide in the copper(II)‐mediated one‐pot three‐component click chemistry to produce radioiodinated iodotriazoles.
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