Association Between Childhood Maltreatment, FKBP5 Gene Methylation, and Anxiety Symptoms Among Chinese Adolescents: A Nested Case-Control Study.
Association Between Childhood Maltreatment, FKBP5 Gene Methylation, and Anxiety Symptoms Among Chinese Adolescents: A Nested Case-Control Study.
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中国青少年童年虐待、FKBP5 基因甲基化与焦虑症状之间的关联：一项巢式病例对照研究
DOI：
10.3389/fpsyt.2022.761898
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发表时间：
2022
影响因子：
4.7
通讯作者：
Lu C
中科院分区：
文献类型：
--
作者：
Lai W;Li W;Du X;Guo Y;Wang W;Guo L;Lu C
焦虑症状是全世界青少年常见的心理健康问题。本研究旨在探讨（1）儿童期虐待与焦虑症状之间的纵向关联；（2）儿童期虐待与 FKBP5 基因 DNA 甲基化之间的关联；（3）FKBP5 基因 DNA 甲基化与随访时焦虑症状的关联。采用巢式病例对照设计，对2019年至2020年广州市13~18岁青少年进行纵向研究，确定病例组和对照组。基线和随访时有焦虑症状的青少年为病例组，基线和随访时无焦虑症状的青少年为对照组。病例组和对照组根据年龄和性别进行匹配。我们的研究最终纳入了 97 例病例和 141 例对照。调整显着协变量后，童年情感虐待与随后的焦虑症状相关（β = 0.146，95% CI = 0.010~0.283）；身体和情感忽视的学生 FKBP5 基因大多数 CpG 单位的 DNA 甲基化水平更可能较低（P < 0.05）； FKBP5-12 CpG 15 甲基化与随访时的焦虑症状相关（β = -0.263，95% CI = -0.458~-0.069）。然而，经过多重假设检验，童年虐待与 FKBP5 DNA 甲基化无关 (q > 0.10)； FKBP5 DNA 甲基化与随后的焦虑症状没有关联 (q > 0.10)。童年时期的情感虐待与中国青少年焦虑症状的风险增加有关。经过多重假设检验，儿童期虐待与 FKBP5 DNA 甲基化没有显着相关性。 FKBP5 基因启动子区域的 DNA 甲基化并不是焦虑症状的重要预测因子。应更加关注遭受童年虐待的青少年的心理健康。
Anxiety symptoms are common mental health problems among adolescents worldwide. This study aimed to explore (1) the longitudinal association between childhood maltreatment and anxiety symptoms, (2) the association between childhood maltreatment and DNA methylation of the FKBP5 gene, and (3) the association of DNA methylation of the FKBP5 gene with anxiety symptoms at follow-up. A nested case-control design was conducted to identify a case group and control group from a longitudinal study of adolescents aged 13–18 years in Guangzhou from 2019 to 2020. Adolescents with anxiety symptoms at baseline and follow-up were considered the case group, while those without anxiety symptoms at baseline and follow-up were considered the control group. The case and control groups were matched according to age and sex. Our study finally included 97 cases and 141 controls. After adjusting for significant covariates, childhood emotional abuse was associated with subsequent anxiety symptoms (β = 0.146, 95% CI = 0.010~0.283); students with physical and emotional neglect were more likely to get a lower level of DNA methylation at most CpG units of FKBP5 gene (P < 0.05); FKBP5-12 CpG 15 methylation was associated with anxiety symptoms at follow-up (β = −0.263, 95% CI = −0.458~-0.069). However, after multiple hypothesis testing, childhood maltreatment was not associated with FKBP5 DNA methylation (q > 0.10); FKBP5 DNA methylation did not show an association with subsequent anxiety symptoms (q > 0.10). Childhood emotional abuse was associated with an increased risk of anxiety symptoms among Chinese adolescents. After multiple hypothesis testing, childhood maltreatment was not significantly associated with FKBP5 DNA methylation. DNA methylation of the promoter region of the FKBP5 gene was not a significant predictor of anxiety symptoms. More attention should be paid to the mental health of adolescents with childhood maltreatment.
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DOI：
10.1007/s11121-016-0691-y
发表时间：
2017-01
期刊：
Prevention science : the official journal of the Society for Prevention Research
影响因子：
--
作者：
Banducci AN;Lejuez CW;Dougherty LR;MacPherson L
通讯作者：
MacPherson L
DOI：
10.1097/00004583-199703000-00012
发表时间：
1997-03-01
影响因子：
13.3
作者：
Bernstein, DP;Ahluvalia, T;Handelsman, L
通讯作者：
Handelsman, L
昼夜皮质醇斜率以及心理和身体健康结果：系统评价和荟萃分析。
影响因子：
3.7
作者：
Adam EK;Quinn ME;Tavernier R;McQuillan MT;Dahlke KA;Gilbert KE
通讯作者：
Gilbert KE
影响因子：
4.6
作者：
Han KM;Won E;Sim Y;Kang J;Han C;Kim YK;Kim SH;Joe SH;Lee MS;Tae WS;Ham BJ
通讯作者：
Ham BJ
影响因子：
4.8
作者：
Bernstein, DP;Stein, JA;Zule, W
通讯作者：
Zule, W