Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis.
Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis.
复制标题
昼夜皮质醇斜率以及心理和身体健康结果：系统评价和荟萃分析。
DOI：
10.1016/j.psyneuen.2017.05.018
复制
发表时间：
2017-09
影响因子：
3.7
通讯作者：
Gilbert KE
中科院分区：
文献类型：
--
作者：
Adam EK;Quinn ME;Tavernier R;McQuillan MT;Dahlke KA;Gilbert KE
压力敏感激素皮质醇水平从早晨到晚上的变化被称为昼夜皮质醇斜率。在过去的理论和研究中，较平坦的昼夜皮质醇斜率被认为是慢性心理社会压力与不良身心健康结果之间的中介。令人惊讶的是，迄今为止，尽管有大量关于该主题的文献，但尚未对昼夜皮质醇斜率与健康之间的关联进行系统或荟萃分析综述。目前的系统综述和荟萃分析研究了昼夜皮质醇斜率与身心健康结果之间的关联。分析基于截至2015年1月31日的80项研究中的179项关联。结果表明，在所有研究中，较平坦的昼夜皮质醇斜率与较差的健康状况之间存在显着关联（平均效应量，r = 0.147）。此外，在检查的12种情绪和身体健康结果中，10种的昼夜皮质醇斜率与健康状况较差有关。在这些亚型中，免疫/炎症结局的效应量最大（r = 0.288）。昼夜皮质醇斜率和健康结果之间的关联的潜在主持人进行了检查，包括斜率测量和研究质量指数的类型。较平坦的斜坡作为一个标志物或疾病的病因机制的可能作用进行了讨论。我们认为，较平坦的昼夜皮质醇斜率可能反映并有助于与压力相关的中枢和外周昼夜节律机制失调，对生物学，行为和健康的多个方面产生相应的下游影响。
Changes in levels of the stress-sensitive hormone cortisol from morning to evening are referred to as diurnal cortisol slopes. Flatter diurnal cortisol slopes have been proposed as a mediator between chronic psychosocial stress and poor mental and physical health outcomes in past theory and research. Surprisingly, neither a systematic nor a meta-analytic review of associations between diurnal cortisol slopes and health has been conducted to date, despite extensive literature on the topic. The current systematic review and meta-analysis examined associations between diurnal cortisol slopes and physical and mental health outcomes. Analyses were based on 179 associations from 80 studies for the time period up to January 31, 2015. Results indicated a significant association between flatter diurnal cortisol slopes and poorer health across all studies (average effect size, r = .147). Further, flatter diurnal cortisol slopes were associated with poorer health in 10 out of 12 subtypes of emotional and physical health outcomes examined. Among these subtypes, the effect size was largest for immune/inflammation outcomes (r = .288). Potential moderators of the associations between diurnal cortisol slopes and health outcomes were examined, including type of slope measure and study quality indices. The possible roles of flatter slopes as either a marker or a mechanism for disease etiology are discussed. We argue that flatter diurnal cortisol slopes may both reflect and contribute to stress-related dysregulation of central and peripheral circadian mechanisms, with corresponding downstream effects on multiple aspects of biology, behavior, and health.
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DOI：
10.1192/bjp.bp.113.126250
发表时间：
2014-02
期刊：
The British journal of psychiatry : the journal of mental science
影响因子：
--
作者：
Carnegie R;Araya R;Ben-Shlomo Y;Glover V;O'Connor TG;O'Donnell KJ;Pearson R;Lewis G
通讯作者：
Lewis G
影响因子：
5.4
作者：
Buss, Julia;Havel, Peter J.;Epel, Elissa;Line, Jue;Blackburn, Elizabeth;Daubenmier, Jennifer
通讯作者：
Daubenmier, Jennifer
影响因子：
3.7
作者：
Adam EK;Heissel JA;Zeiders KH;Richeson JA;Ross EC;Ehrlich KB;Levy DJ;Kemeny M;Brodish AB;Malanchuk O;Peck SC;Fuller-Rowell TE;Eccles JS
通讯作者：
Eccles JS
影响因子：
2.8
作者：
Cermakian N;Lange T;Golombek D;Sarkar D;Nakao A;Shibata S;Mazzoccoli G
通讯作者：
Mazzoccoli G
影响因子：
3.7
作者：
Adam, Emma K.;Doane, Leah D.;Zinbarg, Richard E.;Mineka, Susan;Craske, Michelle G.;Griffith, James W.
通讯作者：
Griffith, James W.