The Dorsolateral Prefrontal Cortex in Acute and Chronic Pain.
The Dorsolateral Prefrontal Cortex in Acute and Chronic Pain.
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DOI：
10.1016/j.jpain.2017.03.008
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Moayedi M
中科院分区：
文献类型：
--
作者：
Seminowicz DA;Moayedi M
背外侧前额叶皮层（DLPFC）是一个功能和结构异质性的区域，是几个大脑网络的关键节点，涉及认知，情感和感觉处理。因此，DLPFC通常在实验性疼痛研究中被激活，并且在慢性疼痛人群中显示出异常增加的功能。此外，一些研究表明，一些慢性疼痛与左侧DLPFC灰质减少有关，成功的干预措施可以逆转这种结构异常。此外，研究表明，非侵入性刺激左侧DLPFC有效地治疗一些慢性疼痛。在这里，我们回顾了神经影像学文献的DLPFC的作用及其作为慢性疼痛条件下的治疗目标的潜力，包括：研究显示参与编码和调制急性疼痛的DLPFC;研究证明逆转DLPFC功能和结构异常后，成功干预慢性疼痛。我们还回顾了DLPFC的非侵入性脑刺激的研究，显示急性疼痛调制和某些慢性疼痛的治疗效果。我们进一步讨论了DLPFC的网络结构，并假设DLPFC刺激缓解慢性疼痛的机制。未来的工作测试这些机制将允许更有效的治疗。
The dorsolateral prefrontal cortex (DLPFC) is a functionally and structurally heterogeneous region and a key node of several brain networks, implicated in cognitive, affective, and sensory processing. As such, the DLPFC is commonly activated in experimental pain studies, and shows abnormally increased function in chronic pain populations. Furthermore, several studies have shown that some chronic pains are associated with decreased left DLPFC gray matter and that successful interventions can reverse this structural abnormality. In addition, studies have indicated that non-invasive stimulation of the left DLPFC effectively treats some chronic pains. Here, we review the neuroimaging literature regarding the role of the DLPFC and its potential as a therapeutic target for chronic pain conditions, including: studies showing the involvement of the DLPFC in encoding and modulating acute pain; studies demonstrating the reversal of DLPFC functional and structural abnormalities following successful interventions for chronic pain. We also review studies of non-invasive brain stimulation of the DLPFC showing acute pain modulation and some effectiveness as a treatment for certain chronic pain conditions. We further discuss the network architecture of the DLPFC, and postulate mechanisms by which DLPFC stimulation alleviates chronic pain. Future work testing these mechanisms will allow for more effective therapies.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1016/j.cortex.2012.05.022
发表时间：
2013-05
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Barbey AK;Koenigs M;Grafman J
通讯作者：
Grafman J
影响因子：
3.7
作者：
Buhle, Jason T.;Silvers, Jennifer A.;Ochsner, Kevin N.
通讯作者：
Ochsner, Kevin N.
影响因子：
5.3
作者：
Apkarian, AV;Sosa, Y;Gitelman, DR
通讯作者：
Gitelman, DR
影响因子：
5.7
作者：
Cole, Michael W.;Schneider, Walter
通讯作者：
Schneider, Walter