Vitamin B6 status of children with sickle cell disease.
Vitamin B6 status of children with sickle cell disease.
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镰状细胞病儿童的维生素 B6 状况。
DOI：
10.1097/00043426-200208000-00011
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Stallings,VirginiaA
中科院分区：
文献类型：
--
作者：
Nelson,MelissaC;Zemel,BabetteS;Kawchak,DeborahA;Barden,ElizabethM;FrongilloJr,EdwardA;Coburn,StephenP;Ohene-Frempong,Kwaku;Stallings,VirginiaA
目的 在体外，维生素 B 6 具有抗镰状化特性，但维生素 B 6 状态对镰状细胞病-SS (SCD-SS) 儿童健康的影响尚未得到很好的描述。本研究的目的是评估 3 至 20 岁 SCD-SS 儿童的维生素 B 6 状态，并确定其与生长、饮食摄入和疾病严重程度的关系。 患者和方法 通过 SCD-SS 受试者的血清 5-磷酸吡哆醛 (PLP) 浓度和其他 SCD-SS 受试者和健康对照儿童的尿液 4-吡哆酸 (4-PA) 浓度来评估维生素 B 6 状态。将 PLP 浓度与生长和营养状况、饮食摄入、血液学指标以及 SCD 相关疾病频率的人体测量指标进行比较。结果 SCD-SS 受试者的 PLP 浓度为 15.6±15.2 nmol/L。 77% 的 PLP 浓度低于膳食参考摄入量（1998 年）建议的缺乏标准（20 nmol/L）。控制碱性磷酸酶、年龄和性别后，PLP 浓度与体重、体重指数和臂围 z 值呈正相关，与网织红细胞计数呈负相关。尽管 4-PA/肌酐值在各组之间没有差异，但 SCD-SS 儿童的尿 4-PA 较低，但在没有过量维生素 B 6 排泄的情况下，SCD-SS 儿童的血清 PLP 浓度明显较低，表明维生素 B 6 状态较低。低血清 PLP 浓度与营养状况不佳的指标相关，并且可能与 SCD-SS 儿童溶血增加有关。
Purpose In vitro, vitamin B 6 has antisickling properties, but the effect of vitamin B 6 status on the health of children with sickle cell disease-SS (SCD-SS) is not well described. The purpose of this study was to assess vitamin B 6 status of children with SCD-SS ages 3 to 20 years and determine its relationship to growth, dietary intake, and disease severity.Patients and Methods Vitamin B 6 status was assessed by serum pyridoxal 5-phosphate (PLP) concentration in subjects with SCD-SS and by urinary 4-pyridoxic acid (4-PA) concentration in other subjects with SCD-SS and healthy control children. Concentration of PLP was compared with anthropometric measures of growth and nutritional status, dietary intake, hematologic indices, and frequency of SCD-related illness.Results The PLP concentration of subjects with SCD-SS was 15.6±15.2 nmol/L. Seventy-seven percent had a PLP concentration below the deficiency criterion (20 nmol/L) suggested by the Dietary Reference Intakes (1998). Controlling for alkaline phosphatase, age, and gender, PLP concentration was associated positively with weight, body mass index, and arm circumference z-scores and negatively with reticulocyte count. Urinary 4-PA was lower in children with SCD-SS versus controls, although 4-PA/creatinine values did not differ between groups.Conclusions Children with SCD-SS had apparently low serum PLP concentrations in the absence of excess vitamin B 6 excretion, suggesting low vitamin B 6 status. Low serum PLP concentration was associated with indicators of poor nutritional status and may be related to increased hemolysis in children with SCD-SS.
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