Clinical review: Major consequences of illicit drug consumption.
Clinical review: Major consequences of illicit drug consumption.
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DOI：
10.1186/cc6166
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发表时间：
2008
期刊：
影响因子：
15.1
通讯作者：
Henry, John A.
中科院分区：
文献类型：
--
作者：
Devlin, Robert J.;Henry, John A.
由于非法药物现在被广泛使用，每个医生都需要了解其严重的医疗后果和并发症。在这里，我们从基于系统的角度回顾与不同药物相关的问题。除了阿片类药物的呼吸抑制作用外，强效可卡因也是导致呼吸系统并发症的最常见原因，这主要与其使用方式有关，气道烧伤、气胸、纵隔气肿和肺部综合征是公认的后遗症。由于其显着的心血管影响，可卡因也是冠状动脉综合征和心肌梗塞的主要原因。安非他明可能会产生类似的效果，但这种情况不太常见。可卡因中毒或 3,4-亚甲二氧基甲基苯丙胺 (MDMA) 劳累或血清素综合征可能会导致体温过高。使用安非他明或可卡因可能导致脑出血。服用LSD、安非他明或可卡因后可能会出现幻觉。 MDMA 是急性严重低钠血症的主要原因，也与肝脏综合征有关。在不同情况下，阿片类药物、MDMA 或 γ 羟基丁酸盐可能会导致虚脱、抽搐或昏迷，其他镇静剂（尤其是酒精和苯二氮卓类药物）可能会加剧这种情况。对这些急性并发症的认识刻不容缓，治疗必须基于对可能的潜在问题的理解以及支持性护理的基本原则。
Because illicit drugs are now widely consumed, every doctor needs to know their acute medical consequences and complications. Here, we review the problems associated with the different drugs from a systems-based viewpoint. Apart from the respiratory depressant effect of opioids, crack cocaine is the most common cause of respiratory complications, mainly linked with its mode of use, with airway burns, pneumothorax, pneumomediastinum, and lung syndromes being well-recognised sequelae. Because of its marked cardiovascular effects, cocaine is also a major cause of coronary syndromes and myocardial infarction. Amphetamines may produce similar effects less commonly. Hyperthermia may occur with cocaine toxicity or with 3,4-methylenedioxymethamphetamine (MDMA) due to exertion or from serotonin syndrome. Cerebral haemorrhage may result from the use of amphetamines or cocaine. Hallucinations may follow consumption of LSD, amphetamines, or cocaine. MDMA is a major cause of acute severe hyponatraemia and also has been linked with hepatic syndromes. Collapse, convulsions, or coma may be caused in different circumstances by opioids, MDMA, or gamma hydroxybutyrate and may be aggravated by other sedatives, especially alcohol and benzodiazepines. Recognition of these acute complications is urgent, and treatment must be based on an understanding of the likely underlying problem as well as on basic principles of supportive care.
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影响因子：
7.3
作者：
Green, AR;O'Shea, E;Colado, MI
通讯作者：
Colado, MI
影响因子：
168.9
作者：
HENRY, JA;JEFFREYS, KJ;DAWLING, S
通讯作者：
DAWLING, S
影响因子：
9.6
作者：
Krantz, AJ;Hershow, RC;Hryhorczuk, DO
通讯作者：
Hryhorczuk, DO
影响因子：
24.5
作者：
Ellis, AJ;Wendon, JA;Williams, R
通讯作者：
Williams, R
影响因子：
25.7
作者：
Andreu, V;Mas, A;Rodés, J
通讯作者：
Rodés, J