The Role of Staphylococcal Biofilm on the Surface of Implants in Orthopedic Infection.
The Role of Staphylococcal Biofilm on the Surface of Implants in Orthopedic Infection.
复制标题
葡萄球菌生物膜在骨科感染中植入物表面的作用。
DOI：
10.3390/microorganisms10101909
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发表时间：
2022-09-26
期刊：
影响因子：
4.5
通讯作者：
Han, Pei
中科院分区：
文献类型：
--
作者：
Lu, Yu;Cai, Wei-jie;Ren, Zun;Han, Pei
尽管有先进的植入物灭菌和无菌手术技术，但植入物相关感染仍然是骨科手术的主要挑战。细菌生物膜的主题正受到越来越多的关注，可能是由于广泛认识到生物膜在临床环境中的普遍存在，以及根除它们的极端困难。生物膜可以被定义为附着在基质上并嵌入其产生的胞外聚合物（EPS）基质中的结构化细胞微生物群落。已经提出生物膜的形成是在多步骤过程中发生的：（i）附着和粘附，（ii）由于细胞聚集和EPS产生的积累/成熟，以及（iii）细菌细胞的生物膜脱离（也称为分散）。在所有这些阶段中，表达特征性蛋白质和非蛋白质化合物，并且它们的表达受到严格控制。种植体周围细菌生物膜的形成会保护细菌并促进感染的持续，这可能导致种植体失败和骨髓炎。这些并发症需要通过大翻修手术和延长抗生素治疗来治疗，这可能导致高昂的治疗费用，甚至增加死亡率。因此，迫切需要有效的预防和治疗措施，以减少种植体相关感染的风险。
Despite advanced implant sterilization and aseptic surgical techniques, implant-associated infection remains a major challenge for orthopedic surgeries. The subject of bacterial biofilms is receiving increasing attention, probably as a result of the wide acknowledgement of the ubiquity of biofilms in the clinical environment, as well as the extreme difficulty in eradicating them. Biofilm can be defined as a structured microbial community of cells that are attached to a substratum and embedded in a matrix of extracellular polymeric substances (EPS) that they have produced. Biofilm development has been proposed as occurring in a multi-step process: (i) attachment and adherence, (ii) accumulation/maturation due to cellular aggregation and EPS production, and (iii) biofilm detachment (also called dispersal) of bacterial cells. In all these stages, characteristic proteinaceous and non-proteinaceous compounds are expressed, and their expression is strictly controlled. Bacterial biofilm formation around implants shelters the bacteria and encourages the persistence of infection, which could lead to implant failure and osteomyelitis. These complications need to be treated by major revision surgeries and extended antibiotic therapies, which could lead to high treatment costs and even increase mortality. Effective preventive and therapeutic measures to reduce risks for implant-associated infections are thus in urgent need.
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影响因子：
16.6
作者：
通讯作者：
--
DOI：
10.1073/pnas.1317181111
发表时间：
2014-01-28
影响因子：
11.1
作者：
Becker, Samuel;Frankel, Matthew B.;Missiakas, Dominique
通讯作者：
Missiakas, Dominique
影响因子：
3.1
作者：
Cramton, SE;Gerke, C;Götz, F
通讯作者：
Götz, F
DOI：
10.1093/cid/ciab426
发表时间：
2021-11-02
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Beldman M;Löwik C;Soriano A;Albiach L;Zijlstra WP;Knobben BAS;Jutte P;Sousa R;Carvalho A;Goswami K;Parvizi J;Belden KA;Wouthuyzen-Bakker M
通讯作者：
Wouthuyzen-Bakker M
影响因子：
3.7
作者：
Bose JL;Lehman MK;Fey PD;Bayles KW
通讯作者：
Bayles KW