Unravelling hair follicle-adipocyte communication.

Unravelling hair follicle-adipocyte communication.
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DOI:
10.1111/exd.12001
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发表时间:
2012-11
影响因子:
3.6
通讯作者:
Horsley V
Horsley V
中科院分区:
医学2区
文献类型:
--
作者:
Schmidt B;Horsley V

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在这里,我们探讨皮内脂肪组织在与毛囊生物学交流中的既定和潜在作用。当毛囊生长到成熟时,它会深入到丰富的真皮大环境中,在那里它被充满脂质的大脂肪细胞包围。皮内脂肪细胞以比其他脂肪组织库更快的动力学再生,并与毛发周期平行,表明毛囊细胞和脂肪细胞之间存在相互作用。虽然脂肪细胞在代谢和能量储存中具有公认的作用,但直到最近,它们作为向邻近皮肤细胞提供重要生长信号的小生境细胞被忽视了。我们讨论了最近的数据支持脂肪细胞作为生态位细胞的皮肤和皮肤病理,可能与皮肤脂肪组织缺陷的改变有关。
Here, we explore the established and potential roles for intradermal adipose tissue in communication with hair follicle biology. The hair follicle delves deep into the rich dermal macroenvironment as it grows to maturity where it is surrounded by large lipid-filled adipocytes. Intradermal adipocytes regenerate with faster kinetics than other adipose tissue depots and in parallel with the hair cycle, suggesting an interplay exists between hair follicle cells and adipocytes. While adipocytes have well-established roles in metabolism and energy storage, until recently, they were overlooked as niche cells that provide important growth signals to neighboring skin cells. We discuss recent data supporting adipocytes as niche cells for the skin and skin pathologies that may be related to alterations in skin adipose tissue defects.
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