A Review of Maternal Nutrition during Pregnancy and Impact on the Offspring through Development: Evidence from Animal Models of Over- and Undernutrition.
A Review of Maternal Nutrition during Pregnancy and Impact on the Offspring through Development: Evidence from Animal Models of Over- and Undernutrition.
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DOI：
10.3390/ijerph17186926
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发表时间：
2020-09-22
影响因子：
--
通讯作者：
Ford SP
中科院分区：
文献类型：
--
作者：
Odhiambo JF;Pankey CL;Ghnenis AB;Ford SP
在怀俄明州大学进行的研究中观察到，由于妊娠期间母体营养不足或营养过剩，后代表型相似。在这些研究中，母羊要么从妊娠早期到中期营养限制（NR），要么从孕前到足月饲喂致肥胖饮食（MO）。在妊娠中期、妊娠晚期和分娩后对后代进行尸检。在妊娠中期，NR胎仔的体重比对照组轻约30%，而MO胎仔比对照组重约30%。出生时，出生的羔羊NR，MO和控制母羊表现出相似的重量。与各自的对照组相比，这是NR母羊的胎儿生长率加速和MO母羊妊娠晚期胎儿生长率降低的结果。这些胎儿生长模式导致了非常相似的影响，增加易感性肥胖，心血管疾病，葡萄糖耐受不良的后代编程主要在胎儿发育阶段。这些数据提供的证据表明，母亲营养不足和营养过剩同样会导致产后出现同样的身体和代谢问题。
Similarities in offspring phenotype due to maternal under- or over-nutrition during gestation have been observed in studies conducted at University of Wyoming. In these studies, ewes were either nutrient-restricted (NR) from early to mid-gestation, or fed an obesogenic diet (MO) from preconception through term. Offspring necropsies occurred at mid-gestation, late-gestation, and after parturition. At mid gestation, body weights of NR fetuses were ~30% lighter than controls, whereas MO fetuses were ~30% heavier than those of controls. At birth, lambs born to NR, MO, and control ewes exhibited similar weights. This was a consequence of accelerated fetal growth rates in NR ewes, and reduced fetal growth rates in MO ewes in late gestation, when compared to their respective controls. These fetal growth patterns resulted in remarkably similar effects of increased susceptibility to obesity, cardiovascular disease, and glucose intolerance in offspring programmed mostly during fetal stages of development. These data provide evidence that maternal under- and over-nutrition similarly induce the development of the same cadre of physical and metabolic problems in postnatal life.
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影响因子：
8
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1097/mpg.0b013e3181977375
发表时间：
2009-03-01
影响因子：
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作者：
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通讯作者：
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作者：
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