Development of a spherically focused phased array transducer for ultrasonic image-guided hyperthermia.
Development of a spherically focused phased array transducer for ultrasonic image-guided hyperthermia.
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DOI：
10.1088/0031-9155/61/14/5275
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发表时间：
2016-07-21
影响因子：
3.5
通讯作者：
Ferrara KW
中科院分区：
文献类型：
--
作者：
Liu J;Foiret J;Stephens DN;Le Baron O;Ferrara KW
设计了一种1.5 MHz长球形治疗阵列，具有128个圆形元件，以适应用于超声图像引导热疗的标准成像阵列。该双阵列系统的实现将实时治疗和成像功能与单个超声系统（Vantage 256，Verasonics）集成。为了促进涉及小动物成像和治疗的应用，该阵列被设计为具有小于3.5 mm的射束景深，并且在轴向和横向方向上在大于1 cm的距离上进行电子转向。为了达到所需的f数0.69，1-3个压电复合材料模块在换能器外壳内配对。原型阵列的性能进行了实验评估与数值模拟非常一致。获得由−6 dB焦点强度定义的焦点体积（2.70 mm（轴向）× 0.65 mm（横向）× 0.35 mm（横向）），以解决小动物治疗所需的尺寸。实现了由−3 dB焦点峰值强度（17 mm（轴向）× 14 mm（横向）× 12 mm（横向））和−8 dB横向栅瓣（24 mm（轴向）× 18 mm（横向）× 16 mm（横向））定义的电子束转向范围。成像和治疗功能的组合测试证实了在组织模拟体模中良好控制的局部产热和成像。这种双阵列实现提供了一种实用的手段，以实现在小动物模型中的热疗和消融，并可以纳入超声介导的药物输送协议。
A 1.5 MHz prolate spheroidal therapeutic array with 128 circular elements was designed to accommodate standard imaging arrays for ultrasonic image-guided hyperthermia. The implementation of this dual-array system integrates real-time therapeutic and imaging functions with a single ultrasound system (Vantage 256, Verasonics). To facilitate applications involving small animal imaging and therapy the array was designed to have a beam depth of field smaller than 3.5 mm and to electronically steer over distances greater than 1 cm in both the axial and lateral directions. In order to achieve the required f number of 0.69, 1-3 piezocomposite modules were mated within the transducer housing. The performance of the prototype array was experimentally evaluated with excellent agreement with numerical simulation. A focal volume (2.70 mm (axial) × 0.65 mm (transverse) × 0.35 mm (transverse)) defined by the −6 dB focal intensity was obtained to address the dimensions needed for small animal therapy. An electronic beam steering range defined by the −3 dB focal peak intensity (17 mm (axial) × 14 mm (transverse) × 12 mm (transverse)) and −8 dB lateral grating lobes (24 mm (axial) × 18 mm (transverse) × 16 mm (transverse)) was achieved. The combined testing of imaging and therapeutic functions confirmed well-controlled local heating generation and imaging in a tissue mimicking phantom. This dual-array implementation offers a practical means to achieve hyperthermia and ablation in small animal models and can be incorporated within protocols for ultrasound-mediated drug delivery.
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DOI：
10.3109/02656736.2015.1094833
发表时间：
2015
期刊：
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
影响因子：
--
作者：
Bing C;Nofiele J;Staruch R;Ladouceur-Wodzak M;Chatzinoff Y;Ranjan A;Chopra R
通讯作者：
Chopra R
影响因子：
4.6
作者：
DICKINSON, RJ
通讯作者：
DICKINSON, RJ
影响因子：
4.4
作者：
Hazle, JD;Diederich, CJ;Stafford, RJ
通讯作者：
Stafford, RJ
影响因子：
3.8
作者：
Chopra, Rajiv;Curiel, Laura;Hynynen, Kullervo
通讯作者：
Hynynen, Kullervo
影响因子：
2.3
作者：
Ebbini, Emad S.;Yao, Hui;Shrestha, Ajay
通讯作者：
Shrestha, Ajay