Environmental chemical exposures among Greenlandic children in relation to diet and residence.

Environmental chemical exposures among Greenlandic children in relation to diet and residence.
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格陵兰儿童与饮食和居住有关的环境化学物质暴露。

DOI:
10.1080/22423982.2019.1642090
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发表时间:
2019
影响因子:
1.3
通讯作者:
Grandjean,Philippe
Grandjean,Philippe
中科院分区:
医学4区
文献类型:
--
作者:
Timmermann,ClaraAmalieGade;Pedersen,HenningSloth;Budtz-Jørgensen,Esben;Bjerregaard,Peter;Oulhote,Youssef;Weihe,Pál;Nielsen,Flemming;Grandjean,Philippe

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本研究的目的是确定格陵兰儿童接触全氟烷基物质(PFASs),多氯联苯(PCBs)和甲基汞的地理,饮食和其他预测因素。该研究包括2012年至2015年期间对367名7至12岁的格陵兰儿童进行检查的横断面数据。父母或监护人参加了一次结构化访谈,并对儿童的血液样本进行了PFAS,PCB和总汞分析。使用线性回归确定环境暴露的预测因子。发现居住区具有最强的解释力,占血清浓度方差的24%至68%。三分之二的儿童可以获得有关饮食的信息,其中,传统格陵兰食物的消费占生物标志物浓度变化的2%至10%。包括与至少一种环境化学物质相关的所有预测因子的模型解释了总方差的19%至54%。总之,面积可能是传统海洋饮食的替代物,面积和饮食共同构成格陵兰儿童接触甲基汞、多氯联苯和全氟辛烷磺酸的最重要预测因素。
The objective of this study was to identify geographic, dietary, and other predictors for childhood exposure to perfluoroalkyl substances (PFASs), polychlorinated biphenyls (PCBs), and methylmercury in Greenlandic children. The study includes cross-sectional data from 367 Greenlandic children aged 7 to 12 years examined during 2012–2015.A parent or guardian participated in a structured interview, and a blood sample from the child was analysed for PFASs, PCBs and total mercury. Predictors for the environmental exposures were identified using linear regression. Area of residence was found to have the strongest explanatory power, accounting for 24% to 68% of the variance in the serum concentrations. Information about diet was available for two-thirds of the children, and among these, consumption of traditional Greenlandic food accounted for 2% to 10% of the variance in the biomarker concentrations. Models including all predictors associated with at least one of the environmental chemicals explained 19% to 54% of the total variance. In conclusion, area is a likely proxy for a traditional marine diet, and together area and diet constitute the most important predictors of exposure to methylmercury, PCBs and PFASs among Greenlandic children.
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