The pinene scaffold: its occurrence, chemistry, synthetic utility, and pharmacological importance.
The pinene scaffold: its occurrence, chemistry, synthetic utility, and pharmacological importance.
复制标题
作者：
植物次生代谢产物是药物发现和新一代药物灵感的主要来源。植物提供了各种各样的化合物类别，包括生物碱、萜烯、黄酮类化合物和糖苷，具有不同的分子结构（稠合桥头、双环和多环、螺环、多环和无环）。植物代谢产物的多样性、丰富性和可获得性使植物成为人类和动物药物的有吸引力的来源。尽管蒎烯支架在自然界中是丰富的，并且在传统医学中具有历史用途，但是还没有对蒎烯和蒎烯衍生的化合物的医学应用进行全面的研究。这篇综述提供了深入了解的效用的蒎烯支架作为一个重要的天然和合成产品的重要组成部分，并作为手性试剂在不对称合成的重要化合物。本文综述了蒎烯在不对称合成中的应用。
Plant-based secondary metabolites have been a major source of drug discovery and inspiration for new generations of drugs. Plants offer a wide variety of compound classes, including alkaloids, terpenes, flavonoids, and glycosides, with different molecular architectures (fused bridgehead, bi- and polycyclic, spirocyclic, polycyclic, and acyclic). The diversity, abundance, and accessibility of plant metabolites make plants an attractive source of human and animal medicine. Even though the pinene scaffold is abundant in nature and has historical use in traditional medicine, pinene and pinene-derived compounds have not been comprehensively studied for medicinal applications. This review provides insight into the utility of the pinene scaffold as a crucial building block of important natural and synthetic products and as a chiral reagent in the asymmetric synthesis of important compounds. This review provides insight into the utility of pinene in the synthetic building block and as reagent in asymmetric synthesis.
登录
查看更多内容
影响因子：
4.9
作者：
Aggarwal, Varinder K.;Ball, Liam T.;Webster, Matthew P.
通讯作者：
Webster, Matthew P.
影响因子：
3.7
作者：
Fernandes, Luciana Sarmento;Mandelli, Dalmo;Bruneau, Christian
通讯作者：
Bruneau, Christian
影响因子：
2.3
作者：
Abrahim, D;Braguini, WL;Ishii-Iwamoto, EL
通讯作者：
Ishii-Iwamoto, EL
影响因子：
6.3
作者：
Ehn, M.;Kleist, E.;Mentel, Th F.
通讯作者：
Mentel, Th F.
影响因子：
3.5
作者：
Bharate, Sandip B.;Khan, Shabana I.;Singh, Inder Pal
通讯作者：
Singh, Inder Pal