Diffusion tensor imaging of normal-appearing white matter as biomarker for radiation-induced late delayed cognitive decline.
Diffusion tensor imaging of normal-appearing white matter as biomarker for radiation-induced late delayed cognitive decline.
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DOI：
10.1016/j.ijrobp.2011.01.068
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发表时间：
2012-04-01
影响因子：
7
通讯作者：
Cao, Yue
中科院分区：
文献类型：
--
作者：
Chapman, Christopher H.;Nagesh, Vijaya;Sundgren, Pia C.;Buchtel, Henry;Chenevert, Thomas L.;Junck, Larry;Lawrence, Theodore S.;Tsien, Christina I.;Cao, Yue
确定早期评估脑白色物质降解是否可以预测放射治疗（RT）后迟发性认知功能下降。10例接受适形分割脑RT的患者参加了前瞻性扩散张量磁共振成像（MRI）研究。在RT前、RT期间3周和6周以及RT开始后10周、30周和78周获得MRI。计算海马旁扣带束和颞叶白色物质的扩散率变量。在RT前和RT后MRI随访时进行生活质量（QOL）调查和神经认知功能测试。在这两种结构中，纵向扩散系数（λ||垂直扩散系数（λ max）增加，且早期变化与后期变化相关（p < 0.05）。放射剂量与3周时扣带回λ max的增加相关，接受戈伊照射的扣带回体积>50%的患者3周和6周时λ max的增加较高（p < 0.05）。RT后言语回忆分数的变化与扣带回λ的晚期变化呈线性相关||（30周，p < 0.02）。通过受试者工作特征曲线，早期扣带λ||变化预测RT后言语回忆评分的变化（3周和6周，p < 0.05）。神经认知测验得分与生活质量调查结果显著相关。海马旁扣带回早期扩散率变化与语言回忆后期下降之间的相关性表明，扩散张量成像可能是预测晚期延迟性认知衰退的生物标志物。
To determine whether early assessment of cerebral white matter degradation can predict late delayed cognitive decline after radiation therapy (RT). Ten patients undergoing conformal fractionated brain RT participated in a prospective diffusion tensor magnetic resonance imaging (MRI) study. MRI was acquired prior to RT, 3 weeks and 6 weeks during RT, and 10, 30, and 78 weeks after starting RT. Diffusivity variables in the parahippocampal cingulum bundle and temporal lobe white matter were computed. Quality of life (QOL) survey and neurocognitive function tests were administered pre-RT and at post-RT MRI follow-ups. In both structures, longitudinal diffusivity (λ||) decreased and perpendicular diffusivity (λ⊥) increased following RT, with early changes correlating to later changes (p < 0.05). Radiation dose correlated with increase in cingulum λ⊥ at 3 weeks, and patients with >50% of cingula volume receiving >12 Gy had a higher increase in λ⊥ at 3 weeks and 6 weeks (p < 0.05). Post-RT changes in verbal recall scores were linearly correlated with late changes in cingulum λ|| (30 weeks, p < 0.02). By receiver operating characteristic curves, early cingulum λ|| changes predicted post-RT changes in verbal recall scores (3 weeks and 6 weeks, p < 0.05). Neurocognitive test scores were significantly correlated with QOL survey results. The correlation between early diffusivity changes in the parahippocampal cingulum and the late decline in verbal recall suggests that diffusion tensor imaging may be useful as a biomarker for predicting late delayed cognitive decline.
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影响因子：
5.7
作者：
Song, SK;Sun, SW;Neufeld, AH
通讯作者：
Neufeld, AH
影响因子：
2.6
作者：
Tombaugh, TN
通讯作者：
Tombaugh, TN
影响因子：
3.9
作者：
Benedict, RHB;Schretlen, D;Brandt, J
通讯作者：
Brandt, J
影响因子：
2.9
作者：
ONO, J;HARADA, K;OKADA, S
通讯作者：
OKADA, S
DOI：
10.1093/jnci/85.5.365
发表时间：
1993-03-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
AARONSON, NK;AHMEDZAI, S;TAKEDA, F
通讯作者：
TAKEDA, F