Doublesex Evolution Is Correlated with Social Complexity in Ants.
Doublesex Evolution Is Correlated with Social Complexity in Ants.
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双性进化与蚂蚁的社会复杂性相关
DOI：
10.1093/gbe/evy250
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发表时间：
2018-12-01
影响因子：
3.3
通讯作者：
Huang DW
中科院分区：
文献类型：
--
作者：
Jia LY;Chen L;Keller L;Wang J;Xiao JH;Huang DW
摘要DMRT(双性和单抗-3相关转录因子)基因是性别决定和性别分化的关键转录因子。在一些群居昆虫中，双性(Dsx)在不同组织和发育阶段表现出广泛的种级特异性表达，被认为是调节群居昆虫分工的候选基因。因此，我们对20只蚂蚁的DMRT基因家族进行了分子进化分析。我们发现，除两个具有系统发育基础的蚂蚁物种(Ponerinae)外，所有蚂蚁都不存在昆虫特有的DsX寡聚结构域，即寡聚结构域2，它们的社会结构和组织与蚂蚁推测的祖先状况相似。系统发育重建和选择分析表明，dsx的进化速度比dmrt家族的其他三个成员快。我们在具有更高级社会组织的蚂蚁亚科(桃金蚁亚科和蚁亚科)中发现了正选择的证据，但在Ponerinae亚科中没有。此外，我们检测了两个DMRT基因dsx和dmrt11E在成年蚂蚁中的表达，并发现dsx在大多数可获得数据的物种中存在明显的男性偏向表达模式。有趣的是，在拥有遗传种姓决定系统的两个蚂蚁物种中，我们没有检测到dsx的男性偏向表达。这些结果可能表明dsx的进化与蚂蚁的社会组织和生殖分工之间存在关联。
Abstract The Dmrt (doublesex and mab-3-related transcription factor) genes are transcription factors crucial for sex determination and sexual differentiation. In some social insects, doublesex (dsx) exhibits widespread caste-specific expression across different tissues and developmental stages and has been suggested as a candidate gene for regulating division of labor in social insects. We therefore conducted a molecular evolution analysis of the Dmrt gene family in 20 ants. We found that the insect-specific oligomerization domain of DSX, oligomerization domain 2, was absent in all ants, except for the two phylogenetically basal ant species (Ponerinae), whose social structure and organization resemble the presumed ancestral condition in ants. Phylogenetic reconstruction and selection analysis revealed that dsx evolved faster than the other three members of the Dmrt family. We found evidence for positive selection for dsx in the ant subfamilies with more advanced social organization (Myrmicinae and Formicinae), but not in the Ponerinae. Furthermore, we detected expression of two Dmrt genes, dsx and DMRT11E, in adult ants, and found a clear male-biased expression pattern of dsx in most species for which data are available. Interestingly, we did not detect male-biased expression of dsx in the two ant species that possess a genetic caste determination system. These results possibly suggest an association between the evolution of dsx and social organization as well as reproductive division of labor in ants.
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DOI：
10.1073/pnas.93.5.2043
发表时间：
1996-03-05
影响因子：
11.1
作者：
Cho, SY;Wensink, PC
通讯作者：
Wensink, PC
对双性基因基因组组织和剪接的新见解，双性基因是家蚕性别分化的终端调节因子
影响因子：
3.7
作者：
Duan J;Xu H;Guo H;O'Brochta DA;Wang F;Ma S;Zhang L;Zha X;Zhao P;Xia Q
通讯作者：
Xia Q
影响因子：
64.8
作者：
Fournier, D;Estoup, A;Keller, L
通讯作者：
Keller, L
影响因子：
4.8
作者：
Cho, S;Wensink, PC
通讯作者：
Wensink, PC
影响因子：
3.3
作者：
Cho, Soochin;Huang, Zachary Y.;Zhang, Jianzhi
通讯作者：
Zhang, Jianzhi