Osteoimmunology: Major and Costimulatory Pathway Expression Associated with Chronic Inflammatory Induced Bone Loss.
Osteoimmunology: Major and Costimulatory Pathway Expression Associated with Chronic Inflammatory Induced Bone Loss.
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DOI：
10.1155/2015/281287
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发表时间：
2015
影响因子：
4.1
通讯作者：
Haynes DR
中科院分区：
文献类型：
--
作者：
Crotti TN;Dharmapatni AA;Alias E;Haynes DR
骨免疫学领域的出现是为了响应一系列证据表明免疫系统和骨代谢之间的密切相互关系。这与免疫介导的疾病有关，如类风湿性关节炎和牙周病，其中存在慢性炎症和局部骨质侵蚀。假体周围骨质溶解是慢性炎症伴骨质溶解的另一个例子。这也可能涉及免疫介导时，发生在患者类风湿性关节炎（RA）。骨丢失的调节和机制的相似性可能与这些疾病中表达的炎性细胞因子有关。这篇综述强调了免疫相关因素对骨丢失的影响，特别是在慢性炎症性疾病中的作用，这些疾病与局部骨丢失有关。讨论了RANKL-RANK-OPG轴平衡的重要性，以及最近认识到的参与免疫受体酪氨酸激活基序（ITAM）信号通路的受体和衔接蛋白的作用。虽然动物模型进行了简要讨论，本次审查的重点是ITAM相关分子的表达与炎症诱导的局部骨丢失在RA，慢性牙周炎，假体周围骨质溶解，强调可溶性和膜结合因子破骨细胞相关受体（OSCAR）。
The field of osteoimmunology has emerged in response to the range of evidences demonstrating the close interrelationship between the immune system and bone metabolism. This is pertinent to immune-mediated diseases, such as rheumatoid arthritis and periodontal disease, where there are chronic inflammation and local bone erosion. Periprosthetic osteolysis is another example of chronic inflammation with associated osteolysis. This may also involve immune mediation when occurring in a patient with rheumatoid arthritis (RA). Similarities in the regulation and mechanisms of bone loss are likely to be related to the inflammatory cytokines expressed in these diseases. This review highlights the role of immune-related factors influencing bone loss particularly in diseases of chronic inflammation where there is associated localized bone loss. The importance of the balance of the RANKL-RANK-OPG axis is discussed as well as the more recently appreciated role that receptors and adaptor proteins involved in the immunoreceptor tyrosine-based activation motif (ITAM) signaling pathway play. Although animal models are briefly discussed, the focus of this review is on the expression of ITAM associated molecules in relation to inflammation induced localized bone loss in RA, chronic periodontitis, and periprosthetic osteolysis, with an emphasis on the soluble and membrane bound factor osteoclast-associated receptor (OSCAR).
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影响因子：
3.7
作者：
Chen DY;Yao L;Chen YM;Lin CC;Huang KC;Chen ST;Lan JL;Hsieh SL
通讯作者：
Hsieh SL
影响因子：
15.3
作者：
Asagiri, M;Sato, K;Takayanagi, H
通讯作者：
Takayanagi, H
影响因子：
9.7
作者：
Alias, E.;Dharmapatni, A. S. S. K.;Haynes, D. R.
通讯作者：
Haynes, D. R.
影响因子：
10.5
作者：
Dougall, WC;Glaccum, M;Schuh, J
通讯作者：
Schuh, J
影响因子：
3.5
作者：
Crotti, Tania N.;Flannery, Merrilee;McHugh, Kevin P.
通讯作者：
McHugh, Kevin P.