Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May-August 2020.
Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May-August 2020.
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DOI：
10.3201/eid2712.210978
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发表时间：
2021-12
影响因子：
11.8
通讯作者：
Henneke P
中科院分区：
文献类型：
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作者：
Stich M;Elling R;Renk H;Janda A;Garbade SF;Müller B;Kräusslich HG;Fabricius D;Zernickel M;Meissner P;Huzly D;Grulich-Henn J;Haddad A;Görne T;Spielberger B;Fritsch L;Nieters A;Hengel H;Dietz AN;Stamminger T;Ganzenmueller T;Ruetalo N;Peter A;Remppis J;Iftner T;Jeltsch K;Waterboer T;Franz AR;Hoffmann GF;Engel C;Debatin KM;Tönshoff B;Henneke P
解决严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 在有不同代际成员的家庭中传播的作用对于遏制当前的大流行至关重要。我们于 2020 年 5 月 11 日至 8 月 1 日在德国西南部进行了一项大规模、多中心、横断面血清流行病学家庭传播研究。我们纳入了来自 405 个家庭的 1,625 名研究参与者，每个家庭都有 ≥1 名儿童和 1 名逆转录 PCR 确诊的 SARS-CoV-2 感染指标病例。总体继发率为 31.6%，暴露成人 (37.5%) 显着高于儿童 (24.6%–29.2%；p = <0.015)；当指标病例患者年龄>60 岁时，该比率也显着较高（72.9%；p = 0.039）。指标病例感染性的其他危险因素包括 SARS-CoV-2 血清阳性（比值比 [OR] 27.8，95% CI 8.26–93.5）、发烧（OR 1.93，95% CI 1.14–3.31）和咳嗽（OR 2.07，95% CI 1.21–3.53）。家庭接触者的继发感染会造成巨大的疾病负担。
Resolving the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in households with members from different generations is crucial for containing the current pandemic. We conducted a large-scale, multicenter, cross-sectional seroepidemiologic household transmission study in southwest Germany during May 11–August 1, 2020. We included 1,625 study participants from 405 households that each had ≥1 child and 1 reverse transcription PCR–confirmed SARS-CoV-2–infected index case-patient. The overall secondary attack rate was 31.6% and was significantly higher in exposed adults (37.5%) than in children (24.6%–29.2%; p = <0.015); the rate was also significantly higher when the index case-patient was >60 years of age (72.9%; p = 0.039). Other risk factors for infectiousness of the index case-patient were SARS-CoV-2–seropositivity (odds ratio [OR] 27.8, 95% CI 8.26–93.5), fever (OR 1.93, 95% CI 1.14–3.31), and cough (OR 2.07, 95% CI 1.21–3.53). Secondary infections in household contacts generate a substantial disease burden.
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DOI：
10.2807/1560-7917.es.2020.25.36.2001587
发表时间：
2020-09
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Ehrhardt J;Ekinci A;Krehl H;Meincke M;Finci I;Klein J;Geisel B;Wagner-Wiening C;Eichner M;Brockmann SO
通讯作者：
Brockmann SO
DOI：
10.1093/infdis/jiaa691
发表时间：
2021-02-13
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Goldstein E;Lipsitch M;Cevik M
通讯作者：
Cevik M
影响因子：
8
作者：
Laws, Rebecca L.;Chancey, Rebecca J.;Kirking, Hannah L.
通讯作者：
Kirking, Hannah L.
影响因子：
36.4
作者：
Macartney, Kristine;Quinn, Helen E.;Wood, Nicholas
通讯作者：
Wood, Nicholas
影响因子：
158.5
作者：
Gudbjartsson, Daniel F.;Norddahl, Gudmundur L.;Stefansson, Kari
通讯作者：
Stefansson, Kari