PROX1 is a predictor of survival for gliomas WHO grade II.
PROX1 is a predictor of survival for gliomas WHO grade II.
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DOI：
10.1038/bjc.2011.162
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发表时间：
2011-05-24
影响因子：
8.8
通讯作者：
Smits, A.
中科院分区：
文献类型：
--
作者：
Elsir, T.;Qu, M.;Berntsson, S. G.;Orrego, A.;Olofsson, T.;Lindstrom, M. S.;Nister, M.;von Deimling, A.;Hartmann, C.;Ribom, D.;Smits, A.
世界卫生组织II级神经胶质瘤的临床过程仍然是可变的，并且它们转化为更恶性表型的时间点是不可预测的。鉴定能够预测个体患者预后的生物学标志物具有重要的临床价值。PROX 1是一种转录因子，在各种器官的发育中起关键作用。PROX 1在人类癌症中具有致癌和肿瘤抑制功能。我们最近发现PROX 1可能作为高级别胶质瘤的诊断标志物。本研究的目的是探讨PROX 1在II级胶质瘤中的预后价值。共评价了116份样本中PROX 1蛋白的存在。免疫阳性细胞的数量与该患者组的既定预后因素一起用作生存分析的变量。PROX 1蛋白水平越高，预后越差。在多变量分析中，PROX 1被确定为生存的独立因素（P=0.024），以及突变的异柠檬酸脱氢酶1 R132 H蛋白的存在，并与染色体臂1 p/19 q的组合损失少突胶质细胞肿瘤。PROX 1是II级胶质瘤生存的新预测因子。
The clinical course of World Health Organisation grade II gliomas remains variable and their time point of transformation into a more malignant phenotype is unpredictable. Identification of biological markers that can predict prognosis in individual patients is of great clinical value. PROX1 is a transcription factor that has a critical role in the development of various organs. PROX1 has been ascribed both oncogenic and tumour suppressive functions in human cancers. We have recently shown that PROX1 may act as a diagnostic marker for high-grade gliomas. The aim of this study was to address the prognostic value of PROX1 in grade II gliomas. A total of 116 samples were evaluated for the presence of PROX1 protein. The number of immunopositive cells was used as a variable in survival analysis, together with established prognostic factors for this patient group. Higher PROX1 protein was associated with poor outcome. In the multivariate analysis, PROX1 was identified as an independent factor for survival (P=0.024), together with the presence of mutated isocitrate dehydrogenase 1 R132H protein, and with combined losses of chromosomal arms 1p/19q in oligodendrocytic tumours. PROX1 is a novel predictor of survival for grade II gliomas.
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影响因子：
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