Osteocyte remodeling of the perilacunar and pericanalicular matrix.

Osteocyte remodeling of the perilacunar and pericanalicular matrix.
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DOI:
10.4248/ijos.09019
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发表时间:
2009-06
影响因子:
14.9
通讯作者:
Bonewald LF
Bonewald LF
中科院分区:
医学1区
文献类型:
--
作者:
Qing H;Bonewald LF

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随着骨细胞的其他功能被识别,骨细胞只是“静态腔隙细胞”的概念不再被接受。我们回顾了大部分关于骨细胞在直接重塑周基质中的功能的相关文献,讨论了其优点和缺点。特别关注负面研究人员如何争论“骨细胞骨质溶解”原理,以及正面研究人员如何处理这些争论。我们还讨论了我们小组新发现的骨细胞重塑功能的数据。随着更多生物技术的掌握,现在能够回答两个重要问题的前景越来越令人兴奋:骨细胞是否有能力从腔周基质中去除矿物质,如果有的话,其分子和细胞机制是什么?骨细胞是否有能力在腔周基质上沉积新的矿物质?如果有的话,其细胞和分子机制是什么?
With additional functions of osteocytes being identified, the concept that osteocytes are just “static lacunar-dwelling cells” is no longer accepted. We reviewed most of the relevant literature on osteocyte's function in the direct remodeling of the perilucunar matrix, discussing the advantages and disadvantages. Special attention was paid to how the negative researchers argue about the “osteocytic osteolysis” principle, and how the positive side addressed the arguments. We also discussed the newly found data of osteocytic remodeling function from our group. With more biotechnology in hand, there is increased excitement in the prospect of now being able to answer the two important questions: do osteocytes have the capability to remove mineral from the perilacunar matrix and if so what are the molecular and cellular mechanisms? do osteocytes have the capability to deposit new mineral on the perilacunar matrix and if so what are the cellular and molecular mechanisms?
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