Postoperative chemotherapy had no prognostic effect on early-staged young ovarian cancer with unilateral resection.
Postoperative chemotherapy had no prognostic effect on early-staged young ovarian cancer with unilateral resection.
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术后化疗对单侧切除的早期年轻卵巢癌没有预后影响
DOI：
10.1002/cam4.1822
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发表时间：
2018-11
期刊：
影响因子：
4
通讯作者：
Yang G
中科院分区：
文献类型：
--
作者：
Zhang X;Wang S;Zhao S;Sun Y;Yang G
术后化疗已广泛用于治疗接受单侧切除术的早期卵巢癌患者，但临床决策主要取决于医生的经验，没有明确的指南。本研究采用倾向评分匹配法分析了行单侧切除术的早期卵巢癌患者术后化疗对预后的影响。从2000 - 2018年的监测、流行病学和最终结果项目数据库中探索了50岁或50岁以下的早期卵巢癌患者。倾向评分匹配用于随机化数据集并减少选择偏倚。应用单变量和多变量考克斯比例风险模型估计化疗的必要性。在匹配人群的单变量分析中，总生存期和癌症特异性生存期分析均显示化疗对早期年轻卵巢癌患者的预后无影响（总生存期，P = 0.477;癌症特异性生存期，P = 0.950）。在倾向调整的多变量分析中，排除所有混杂因素的影响后，化疗对总体和癌症特异性生存概率均无影响（HR = 0.863，CI = 0.587 - 1.269，P = 0.455; HR = 1.009，CI = 0.633 - 1.607，P = 0.970）。我们的研究表明，对于单侧切除的早期年轻卵巢癌患者，术后化疗是不必要的，如总生存率和癌症特异性生存率所示。
Postoperative chemotherapy has been widely used in the treatment of early‐staged ovarian cancer patients underwent unilateral resection, but the clinical decision mainly depends on the doctor’s experience without a well‐defined guideline. This study used propensity score matching to analyze the effect of postoperative chemotherapy for early‐staged ovarian cancer patients underwent unilateral resection on prognosis. Patients of age 50 or younger than 50 with early‐staged ovarian cancer were explored from the Surveillance, Epidemiology, and End Results program database during 2000‐2018. Propensity score matching was used to randomize the dataset and reduce the selection biases. Univariate and multivariate cox proportional hazards models were utilized to estimate the necessity of chemotherapy. In univariate analysis of matched population, both the overall survival and cancer‐specific survival analysis showed that chemotherapy had no effect on the prognosis of early‐staged young ovarian cancer patients (Overall survival, P = 0.477; Cancer‐specific survival, P = 0.950). In propensity‐adjusted multivariate analysis, chemotherapy still had no effect on both the overall and cancer‐specific survival probability after excluding the effect of all the confounding factors (HR = 0.863, CI = 0.587‐1.269, P = 0.455; HR = 1.009, CI = 0.633‐1.607, P = 0.970). Our study suggested that postoperative chemotherapy is not necessary for early‐staged young ovarian cancer patients with unilateral resection, as indicated by both the overall survival and cancer‐specific survival.
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影响因子：
4.6
作者：
Boehmerle W;Huehnchen P;Peruzzaro S;Balkaya M;Endres M
通讯作者：
Endres M
影响因子：
--
作者：
Ozkok A;Edelstein CL
通讯作者：
Edelstein CL
影响因子：
254.7
作者：
Siegel, Rebecca;Ma, Jiemin;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
3.3
作者：
Weaver BA
通讯作者：
Weaver BA
DOI：
10.2174/1568011053765967
发表时间：
2005-05-05
期刊：
Current Medicinal Chemistry - Anti-Cancer Agents
影响因子：
--
作者：
Sedletska, Yuliya;Giraud-Panis, Marie-Josephe;Malinge, Jean-Marc
通讯作者：
Malinge, Jean-Marc