Heterogenic feedback between hindlimb extensors in the spontaneously locomoting premammillary cat.
Heterogenic feedback between hindlimb extensors in the spontaneously locomoting premammillary cat.
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自发运动前乳头猫后肢伸肌之间的异质反馈。
DOI：
10.1152/jn.90338.2008
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发表时间：
2009
影响因子：
2.5
通讯作者：
Nichols,TRichard
中科院分区：
文献类型：
--
作者：
Ross,KylaT;Nichols,TRichard
在麻醉动物的电生理学研究表明，从高尔基体腱器官的反重力肌肉的力信息的途径介导广泛的抑制之间的其他反重力肌肉在猫后肢。最近的证据表明，在瘫痪或非瘫痪的去大脑猫，一些抑制性通路被抑制和单独的兴奋性通路从高尔基体腱器官传入打开的过渡，从稳定的力量生产的自发活动。为了进一步了解这些通路在运动过程中的功能，我们研究了在自发运动过程中和在乳头体前去脑猫的恒定用力过程中力依赖性抑制和兴奋的分布。我们使用四个伺服控制拉伸设备以各种组合对腓肠肌（G），跖肌（PNL），拇长屈肌（FHL），和四头肌（QUADS）在跑步机步进和交叉伸展反射（XER）。我们记录了来自相同肌肉的力反应，因此能够评估这组肌肉之间的自生（肌内）和异源（肌间）反射。在以前的研究中，使用丘间去脑猫，QUADS，G，FHL，和ESTA之间的异源抑制是双向的。在跑步机步进，异源反馈从QUADS到G和G到ESTA和FHL保持抑制和力依赖性。然而，异源性抑制，从ESTA和FHL到G，从G到QUADS，是弱于在XER。我们认为，在水平表面上的某些形式的运动下，介导异源抑制的途径可能仍然具有抑制作用，但这些途径的强度发生变化，导致近端到远端的抑制梯度。异源抑制的潜在贡献，关节间的协调和肢体的稳定性进行了讨论。
Electrophysiological studies in anesthetized animals have revealed that pathways carrying force information from Golgi tendon organs in antigravity muscles mediate widespread inhibition among other antigravity muscles in the feline hindlimb. More recent evidence in paralyzed or nonparalyzed decerebrate cats has shown that some inhibitory pathways are suppressed and separate excitatory pathways from Golgi tendon organ afferents are opened on the transition from steady force production to locomotor activity. To obtain additional insight into the functions of these pathways during locomotion, we investigated the distribution of force-dependent inhibition and excitation during spontaneous locomotion and during constant force exertion in the premammillary decerebrate cat. We used four servo-controlled stretching devices to apply controlled stretches in various combinations to the gastrocnemius muscles (G), plantaris muscle (PLAN), flexor hallucis longus muscle (FHL), and quadriceps muscles (QUADS) during treadmill stepping and the crossed-extension reflex (XER). We recorded the force responses from the same muscles and were therefore able to evaluate autogenic (intramuscular) and heterogenic (intermuscular) reflexes among this set of muscles. In previous studies using the intercollicular decerebrate cat, heterogenic inhibition among QUADS, G, FHL, and PLAN was bidirectional. During treadmill stepping, heterogenic feedback from QUADS onto G and G onto PLAN and FHL remained inhibitory and was force-dependent. However, heterogenic inhibition from PLAN and FHL onto G, and from G onto QUADS, was weaker than during the XER. We propose that pathways mediating heterogenic inhibition may remain inhibitory under some forms of locomotion on a level surface but that the strengths of these pathways change to result in a proximal to distal gradient of inhibition. The potential contributions of heterogenic inhibition to interjoint coordination and limb stability are discussed.
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DOI：
10.1016/0002-9343(71)90230-0
发表时间：
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期刊：
The American journal of medicine
影响因子：
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作者：
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DOI：
--
发表时间：
1980
期刊：
A M A Archives of Ophthalmology
影响因子：
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作者：
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影响因子：
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作者：
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