Comparing the performances of electrochemical sensors using p-aminophenol redox cycling by different reductants on gold electrodes modified with self-assembled monolayers
Comparing the performances of electrochemical sensors using p-aminophenol redox cycling by different reductants on gold electrodes modified with self-assembled monolayers
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比较使用不同还原剂在自组装单层修饰的金电极上进行对氨基苯酚氧化还原循环的电化学传感器的性能
DOI：
10.1016/j.electacta.2013.07.118
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发表时间：
2013-10
影响因子：
6.6
通讯作者：
Lin Liu
中科院分区：
文献类型：
--
作者：
Jimin Du;Sujuan Li;Jing Chen;Lin Liu
利用化学还原剂进行对氨基苯酚(p-AP)氧化还原循环是发展灵敏电化学传感器的一种策略。然而，由于还原剂在高度电催化的金电极上的氧化反应产生的背景电流较大，目前报道的大多数还原剂只用于ITO电极，而不用于金电极。因此，需要新的策略和/或还原剂来扩大p-AP氧化还原循环在金电极上的应用。在这项工作中，我们比较了几种还原剂在自组装单分子膜修饰的金电极上进行p-AP氧化还原循环的性能。在所测试的试剂中，烟酰胺腺嘌呤二核苷酸(NADH)、三(2-羧乙基)膦(TCEP)和半胱胺由于背景电流小，适合在烷硫醇修饰的金电极上进行p-AP氧化还原循环。还原剂与对苯二酚亚胺(P-AP的电化学氧化产物QI)之间的化学反应速度按NADH、TCEP、半胱胺的顺序递增。该体系具有背景电流小、化学反应快、以TCEP或半胱胺为还原剂的传感器的适应性和灵敏度的优点；通过对microRNA的检测，证明了这些性能的增强。L−-1的检出限为2pmoL。我们相信，我们的工作将对发展金电极上的p-AP氧化还原循环电化学传感器具有一定的参考价值。
p-Aminophenol (p-AP) redox cycling using chemical reductants is one strategy for developing sensitive electrochemical sensors. However, most of the reported reductants are only used on indium-tin oxide (ITO) electrodes but not gold electrodes due to the high background current caused by the oxidation reaction of the reductants on the highly electrocatalytic gold electrodes. Therefore, new strategies and/or reductants are in demand for expanding the application of p-AP redox cycling on gold electrodes. In this work, we compared the performances of several reductants in p-AP redox cycling on self-assembled monolayers (SAMs)-modified gold electrodes. Among the tested reagents, nicotinamide adenine dinucleotide (NADH), tris(2-carboxyethyl)phosphine (TCEP) and cysteamine were demonstrated to be suitable for p-AP redox cycling on the alkanethiol-modified gold electrodes because of their low background current. The rate of chemical reaction between reductants andp-quinone imine (QI, the electrochemically oxidized product of p-AP) increases in the order of NADH < TCEP < cysteamine. The system benefits from the low background current, fast chemical reaction and amenability and sensitivity of the sensor with TCEP or cysteamine as the reductant; these performance enhancements were demonstrated by the detection of microRNA. A detection limit of 2 pmol L−1was achieved. We believe that our work will be valuable for the development of electrochemical sensors using p-AP redox cycling on gold electrodes.
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