Concentrated autologous bone marrow aspirate transplantation treatment for corticosteroid-induced osteonecrosis of the femoral head in systemic lupus erythematosus.
Concentrated autologous bone marrow aspirate transplantation treatment for corticosteroid-induced osteonecrosis of the femoral head in systemic lupus erythematosus.
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DOI：
10.1007/s00264-010-1048-y
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发表时间：
2011-06
影响因子：
2.7
通讯作者：
Ochiai, Naoyuki
中科院分区：
文献类型：
--
作者：
Yoshioka, Tomokazu;Mishima, Hajime;Akaogi, Hiroshi;Sakai, Shinsuke;Li, Meihua;Ochiai, Naoyuki
本研究的目的是评估浓缩自体骨髓抽吸移植（CABMAT）治疗皮质类固醇诱导的系统性红斑狼疮（SLE）股骨头骨坏死（ONFH）。从髂骨嵴抽取骨髓，用传统的手工血袋离心技术进行浓缩，该技术用于提取灰褐色的毛发，然后通过钻孔将骨髓注入9个髋关节。移植平均有核细胞数为5.32 × 107个/ml。该细胞浓度经浓缩后显著升高，平均浓度比为5.5。在随访（至少3年）中，观察到疼痛和Harris髋关节评分显著改善。我们成功地保存了9个髋关节中的8个的股骨头。然而，其中一个髋关节在术后45个月需要全髋关节置换术。使用我们的离心技术的CABMAT是一种有效、安全、低成本的治疗性成骨方法，用于治疗SLE中皮质类固醇诱导的ONFH。
The purpose of this study was to evaluate concentrated autologous bone marrow aspirate transplantation (CABMAT) treatment for corticosteroid-induced osteonecrosis of the femoral head (ONFH) in systemic lupus erythematosus (SLE). Bone marrow was aspirated from iliac crests, concentrated on a conventional manual blood bag centrifugation technique that is used to extract buffy coats and then injected into nine hips with drilling. The mean number of nucleated cells for transplantation was 5.32 × 107 cells/ml. This cell concentration was significantly higher after concentration, and the mean concentration ratio was 5.5. At follow-up (minimum: three years), significant improvement in pain and Harris Hip Score was observed. For eight of nine hips, we successfully preserved the femoral head. However, one hip required total hip arthroplasty 45 months after the operation. CABMAT using our centrifugation technique is an effective, safe and low-cost procedure of therapeutic osteogenesis for corticosteroid-induced ONFH in SLE.
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影响因子：
5.2
作者：
Lee, HS;Huang, GT;Jiang, CC
通讯作者：
Jiang, CC
DOI：
10.1007/s007760200108
发表时间：
2002-01-01
期刊：
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
影响因子：
--
作者：
Sugano, Nobuhiko;Atsumi, Takashi;Takaoka, Kunio
通讯作者：
Takaoka, Kunio
DOI：
10.1097/01.blo.0000038472.05771.79
发表时间：
2002-12-01
影响因子：
4.2
作者：
Hernigou, P;Beaujean, F
通讯作者：
Beaujean, F
DOI：
10.1302/0301-620x.87b7.16289
发表时间：
2005-07-01
影响因子：
--
作者：
Hernigou, P;Poignard, A;Rouard, H
通讯作者：
Rouard, H
股骨头坏死的病灶大小变化：使用 MRI 的长期前瞻性研究。
影响因子：
2.7
作者：
Zhao, Feng-chao;Li, Zi-rong;Zhang, Nian-fei;Wang, Bai-liang;Sun, Wei;Cheng, Li-ming;Liu, Zhao-hui
通讯作者：
Liu, Zhao-hui