The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors.
The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors.
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作者：
Moore XTR;Gheghiani L;Fu Z
Polo样激酶1（PLK 1）是一种丝氨酸/苏氨酸激酶，具有600多种磷酸化底物，通过这些底物，它调节许多生物过程，包括有丝分裂、凋亡、代谢、RNA加工、囊泡转运和G2 DNA损伤检查点恢复等。在许多PLK 1靶点中，有FOX家族转录因子（FOX TF）的成员，包括FOXM 1、FOXO 1、FOXO 3和FOXK 1。FOXM 1和FOXK 1通过拮抗凋亡信号和促进细胞增殖、转移、血管生成和治疗抗性在癌症中具有关键的致癌作用。相反，FOXO 1和FOXO 3已被鉴定为在维持细胞内稳态方面具有广泛的功能。在这篇综述中，我们讨论了PLK 1介导的FOX TF的调节，突出PLK 1对这些蛋白质的活性和稳定性的影响。此外，我们还回顾了这些蛋白在人类癌症中的预后和临床意义，更重要的是，已用于破坏PLK 1和FOX TF介导的信号网络的不同方法。此外，我们还讨论了靶向PLK 1调节的FOX TF在人类癌症中的治疗潜力。
Polo-like kinase 1 (PLK1) is a serine/threonine kinase with more than 600 phosphorylation substrates through which it regulates many biological processes, including mitosis, apoptosis, metabolism, RNA processing, vesicle transport, and G2 DNA-damage checkpoint recovery, among others. Among the many PLK1 targets are members of the FOX family of transcription factors (FOX TFs), including FOXM1, FOXO1, FOXO3, and FOXK1. FOXM1 and FOXK1 have critical oncogenic roles in cancer through their antagonism of apoptotic signals and their promotion of cell proliferation, metastasis, angiogenesis, and therapeutic resistance. In contrast, FOXO1 and FOXO3 have been identified to have broad functions in maintaining cellular homeostasis. In this review, we discuss PLK1-mediated regulation of FOX TFs, highlighting the effects of PLK1 on the activity and stability of these proteins. In addition, we review the prognostic and clinical significance of these proteins in human cancers and, more importantly, the different approaches that have been used to disrupt PLK1 and FOX TF-mediated signaling networks. Furthermore, we discuss the therapeutic potential of targeting PLK1-regulated FOX TFs in human cancers.
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影响因子：
3
作者：
Chen YH;Li CL;Chen WJ;Liu J;Wu HT
通讯作者：
Wu HT
影响因子：
14.9
作者：
Andrysik Z;Bernstein WZ;Deng L;Myer DL;Li YQ;Tischfield JA;Stambrook PJ;Bahassi el M
通讯作者：
Bahassi el M
影响因子：
50.3
作者：
Anders L;Ke N;Hydbring P;Choi YJ;Widlund HR;Chick JM;Zhai H;Vidal M;Gygi SP;Braun P;Sicinski P
通讯作者：
Sicinski P
影响因子：
3.2
作者：
Hymel D;Tsuji K;Grant RA;Chingle RM;Kunciw DL;Yaffe MB;Burke TR Jr
通讯作者：
Burke TR Jr
影响因子：
4.4
作者：
Anderson, MJ;Viars, CS;Arden, KC
通讯作者：
Arden, KC