Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis.
Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis.
复制标题
代谢综合征会增加膝骨关节炎的风险：荟萃分析
DOI：
10.1155/2016/7242478
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Zha Z
中科院分区：
文献类型：
--
作者：
Wang H;Cheng Y;Shao D;Chen J;Sang Y;Gui T;Luo S;Li J;Chen C;Ye Y;Yang Y;Li Y;Zha Z
Background. Studies revealed that metabolic factors might contribute substantially to osteoarthritis (OA) pathogenesis. There has been an increasing interest to understand the relationship between knee OA and the metabolic syndrome (MetS). The purpose of this study was to explore the association between metabolic syndrome and knee osteoarthritis using meta-analysis. Methods. Databases, including PUBMED, EMBASE, and the Cochrane Library, were searched to get relevant studies. Data were extracted separately by two authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Results. The meta-analysis was finished with 8 studies with a total of 3202 cases and 20968 controls finally retrieved from the database search. The crude pooled OR is 2.24 (95% CI = 1.38–3.64). Although there was significant heterogeneity among these studies, which was largely accounted for by a single study, the increase in risk was still significant after exclusion of that study. The pooled adjusted OR remained significant with pooled adjusted OR 1.05 (95% CI = 1.03–1.07, p < 0.00001). No publication bias was found in the present meta-analysis. Conclusions. The synthesis of available evidence supports that metabolic syndrome increases the risk for knee osteoarthritis, even after adjustment for many risk factors.
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