The epidemiology and impact of pain in osteoarthritis.

The epidemiology and impact of pain in osteoarthritis.
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DOI:
10.1016/j.joca.2013.03.018
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发表时间:
2013-09
影响因子:
7
通讯作者:
Neogi, T.
Neogi, T.
中科院分区:
医学2区
文献类型:
--
作者:
Neogi, T.

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骨关节炎是关节炎的最常见形式,也是全世界残疾的主要原因,主要是由于疼痛,这种疾病的主要症状。特别是膝关节骨关节炎的疼痛经历被公认为通常从间歇性负重疼痛转变为更持久的慢性疼痛。已经开发了有效评估骨关节炎研究中疼痛的方法,以解决疼痛体验的复杂性。骨关节炎疼痛的病因被认为是多因素的,关节内和关节外的风险因素。尽管如此,需要更深入地了解骨关节炎的疼痛机制,以实现基于机制的合理疼痛管理。与骨关节炎相关的疼痛后果造成了巨大的社会经济负担。
Osteoarthritis is the most common form of arthritis and a leading cause of disability worldwide, largely due to pain, the primary symptom of the disease. The pain experience in knee osteoarthritis in particular is well-recognized as typically transitioning from intermittent weight-bearing pain to a more persistent, chronic pain. Methods to validly assess pain in osteoarthritis studies have been developed to address the complex nature of the pain experience. The etiology of pain in osteoarthritis is recognized to be multifactorial, with both intra-articular and extra-articular risk factors. Nonetheless, greater insights are needed into pain mechanisms in osteoarthritis to enable rational mechanism-based management of pain. Consequences of pain related to osteoarthritis contribute to a substantial socioeconomic burden.
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