Effect of Atrial Natriuretic Peptide on Vascular Permeation in the Ovine Fetus
Effect of Atrial Natriuretic Peptide on Vascular Permeation in the Ovine Fetus
复制标题
心钠素对羊胎儿血管通透性的影响
作者：
M. Silberbach;Debra F. Anderson;M. Reller;L. Davis
摘要：为探讨心钠素(ANP)对胎儿白蛋白血管通透性的影响，对8例绵羊胎儿输注心钠素(167~600 ng/min)，8例双胎(胎龄127±3d)输注生理盐水50min。使用两种不同的放射性标记白蛋白标志物，我们测定了组织与血液的同位素比率(TBIR)、白蛋白通透性指数和白蛋白清除率。尽管心钠素对血液动力学无影响，但输注心钠素的胎儿的红细胞压积明显高于初值(0.37±0.04vs0.42±0.04，p<；0.005)，而注射生理盐水的双胎的红细胞压积无明显变化(0.35±0.03vs0.35±0.02)。与生理盐水对照组相比，注射心钠素的胎儿联合组织的总胆红素和白蛋白渗透率增加(分别为1.49±0.58vs1.29±0.3，p<；0.001；白蛋白清除率：1091±1279vs827±1464mL/g/min，p<；0.01)。在单个组织中，皮肤(2.88±0.67比1.55±0.35，p<；0.02)、肌肉(1.6±0.27比1.24±0.26，p<；0.02)、肾上腺(1.33±0.10比1.13±0.15，p<；0.02)、骨(1.67±0.45比1.20±0.40，p<；0.02)显著增加。0.02)、肾脏(1.52±0.25比1.24±0.26，p<；0.03)和肠道(1.69±0.20比1.39±0.34，p<；0.03)。白蛋白清除率在大多数组织中较高，但仅在皮肤(2135±944比775±847毫升/克/分，p<；0.05)和骨(1012±1107比428±482nL/g/min，p<；0.05)达到统计学意义。我们得出结论，胎儿的整体血管滤过率高于成人。输注ANP会导致胎儿血液浓缩，减少血容量，并增强白蛋白在大多数组织中的血管渗透性，特别是胎儿皮肤。我们推测，心脏心房通过分泌ANP，通过维持血管内和血管外液体间的临界平衡来参与血容量调节。心钠素系统的失调可能会导致胎儿积水。
ABSTRACT: To study the effect of atrial natriuretic peptide (ANP) on vascular permeation of albumin in the fetus, ANP (167–600 ng/min) was infused into eight ovine fetuses and saline vehicle was infused into eight twin controls (gestational age 127 ± 3 d) over a 50-min period. Using two different radiolabeled albumin markers, we determined the tissue to blood isotope ratio (TBIR), an index of albumin permeation, and the albumin clearance. Although ANP had no hemodynamic effect, a marked increase in the hematocrit was observed in ANP-infused fetuses compared with initial values (0.37 ± 0.04 vs 0.42 ± 0.04, p < 0.005) but was unchanged in the twin fetuses receiving saline vehicle (0.35 ± 0.03 versus 0.35 ± 0.02). TBIR and albumin permeation were increased in combined tissues of ANP-infused fetuses compared with saline controls (TBIR: 1.49 ± 0.58 versus 1.29 ± 0.3, p < 0.001; albumin clearance: 1091 ± 1279 versus 827 ± 1464 mL/g/min, p < 0.01). In individual tissues, TBIR was significantly increased in skin (2.88 ± 0.67 versus 1.55 ± 0.35, p < 0.02), muscle (1.6 ± 0.27 versus 1.24 ± 0.26, p < 0.02), adrenal (1.33 ± 0.10 versus 1.13 ± 0.15, p < 0.02), bone (1.67 ± 0.45 versus 1.20 ± 0.40, p < 0.02), kidney (1.52 ± 0.25 versus 1.24 ± 0.26, p < 0.03), and gut (1.69 ± 0.20 versus 1.39 ± 0.34, p < 0.03). Albumin clearance was higher in most tissues but reached statistical significance only in skin (2135 ± 944 versus 775 ± 847 mL/g/min, p < 0.05) and bone (1012 ± 1107 versus 428 ±482 nL/g/min, p < 0.05). We conclude that overall vascular filtration is higher in the fetus than the adult. Infusion of ANP causes fetal hemoconcentration, decreases blood volume, and enhances vascular permeation of albumin in most tissues, particularly fetal skin. We speculate that the cardiac atria, by secreting ANP, participate in blood volume regulation by maintaining a critical balance between the intravascular and extravascular fluid compartments. Dysregulation of the ANP system might result in fetal hydrops.
绵羊肾脏对利尿钠肽反应的个体发育。
DOI：
10.1152/ajprenal.1988.254.5.f634
发表时间：
1988
期刊：
The American journal of physiology
影响因子：
--
作者：
Robillard,JE;Nakamura,KT;Varille,VA;Andresen,AA;Matherne,GP;VanOrden,DE
通讯作者：
VanOrden,DE
胎儿心血管、内分泌和体液对心房钠尿因子输注的反应。
DOI：
10.1152/ajpregu.1989.257.3.r580
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Brace,RA;Bayer,LA;Cheung,CY
通讯作者：
Cheung,CY