Plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large Asian population.
Plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large Asian population.
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DOI：
10.1186/s12199-017-0642-7
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发表时间：
2017-04-07
影响因子：
4.7
通讯作者：
Tanabe T
中科院分区：
文献类型：
--
作者：
Yamaguchi N;Mahbub MH;Takahashi H;Hase R;Ishimaru Y;Sunagawa H;Amano H;Kobayashi-Miura M;Kanda H;Fujita Y;Yamamoto H;Yamamoto M;Kikuchi S;Ikeda A;Takasu M;Kageyama N;Nakamura M;Tanabe T
近年来，血浆游离氨基酸（PFAA）谱与生活方式相关疾病的关联已被报道。然而，很少有研究报告，在亚洲大人口，对PFAAs的有用性，以评估疾病的风险。我们研究了PFAA谱评估迄今为止最大的亚洲人群中生活方式相关疾病的能力。我们检测了8589名日本受试者的19种氨基酸的血浆浓度，并确定了与肥胖、血糖、血脂和血压相关的变量之间的关系。我们还评估了反映内脏脂肪肥胖和胰岛素抵抗的PFAA指数。此外，还考察了PFAA单项水平和相关PFAA指标在生活方式相关疾病风险评估中的贡献。在19种氨基酸中，支链氨基酸和芳香族氨基酸与肥胖和脂质变量相关。与内脏脂肪肥胖相关的PFAA指数与变量的相关性高于任何PFAA指数。在生活方式相关疾病风险的评估中，即使在调整了潜在的混杂因素后，与内脏脂肪肥胖或胰岛素抵抗相关的PFAA指数与疾病的比值比仍高于大多数个体氨基酸水平。这些指标和PFAA与每种生活方式相关疾病的关联模式不同。我们证实了PFAA谱和指数作为评估生活方式相关疾病风险的标志物的有用性，包括糖尿病、代谢综合征、血脂异常和高血压。
Recently, the association of plasma free amino acid (PFAA) profile and lifestyle-related diseases has been reported. However, few studies have been reported in large Asian populations, about the usefulness of PFAAs for evaluating disease risks. We examined the ability of PFAA profiles to evaluate lifestyle-related diseases in so far the largest Asian population. We examined plasma concentrations of 19 amino acids in 8589 Japanese subjects, and determined the association with variables associated with obesity, blood glucose, lipid, and blood pressure. We also evaluated the PFAA indexes that reflect visceral fat obesity and insulin resistance. The contribution of single PFAA level and relevant PFAA indexes was also examined in the risk assessment of lifestyle-related diseases. Of the 19 amino acids, branched-chain amino acids and aromatic amino acids showed association with obesity and lipid variables. The PFAA index related to visceral fat obesity showed relatively higher correlation with variables than that of any PFAA. In the evaluation of lifestyle-related disease risks, the odds ratios of the PFAA index related to visceral fat obesity or insulin resistance with the diseases were higher than most of those of individual amino acid levels even after adjusting for potential confounding factors. The association pattern of the indexes and PFAA with each lifestyle-related disease was distinct. We confirmed the usefulness of PFAA profiles and indexes as markers for evaluating the risks of lifestyle-related diseases, including diabetes mellitus, metabolic syndrome, dyslipidemia, and hypertension in a large Asian population.
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影响因子：
4.6
作者：
Yamakado M;Nagao K;Imaizumi A;Tani M;Toda A;Tanaka T;Jinzu H;Miyano H;Yamamoto H;Daimon T;Horimoto K;Ishizaka Y
通讯作者：
Ishizaka Y
影响因子：
3.7
作者：
Miyagi Y;Higashiyama M;Gochi A;Akaike M;Ishikawa T;Miura T;Saruki N;Bando E;Kimura H;Imamura F;Moriyama M;Ikeda I;Chiba A;Oshita F;Imaizumi A;Yamamoto H;Miyano H;Horimoto K;Tochikubo O;Mitsushima T;Yamakado M;Okamoto N
通讯作者：
Okamoto N
影响因子：
7.7
作者：
Würtz P;Mäkinen VP;Soininen P;Kangas AJ;Tukiainen T;Kettunen J;Savolainen MJ;Tammelin T;Viikari JS;Rönnemaa T;Kähönen M;Lehtimäki T;Ripatti S;Raitakari OT;Järvelin MR;Ala-Korpela M
通讯作者：
Ala-Korpela M
影响因子：
29
作者：
Newgard CB
通讯作者：
Newgard CB
影响因子：
5.2
作者：
Ma RC;Chan JC
通讯作者：
Chan JC