Gut instincts in neuroimmunity from the eighteenth to twenty-first centuries.
Gut instincts in neuroimmunity from the eighteenth to twenty-first centuries.
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DOI：
10.1007/s00281-022-00948-2
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发表时间：
2022-09
影响因子：
9
通讯作者：
Palm, Noah W.
中科院分区：
文献类型：
--
作者：
Nguyen, Mytien;Palm, Noah W.
在过去的二十年里，关于微生物-肠道-大脑轴的研究使人们重新认识到临床和科学界身体系统之间的相互联系。仅在美国，就有数百万成年人患有非传染性慢性疾病，这些疾病的假定病因以前被认为仅限于肠道或大脑，如炎症性肠病、肠易激综合征、帕金森病和阿尔茨海默病以及自闭症谱系障碍。然而，最近对肠道微生物组对人类健康各个方面的影响的研究激增，揭示了肠道微生物组，免疫系统和大脑在各种疾病和病症中相互作用的潜在关键重要性。在这篇综述中，我们回顾了科学和医学中肠-脑相互作用的历史，这至少可以追溯到18世纪，并概述了这一领域的概念是如何跨越时代转变和演变的。接下来，我们将重点介绍肠-脑轴研究的现代复兴，重点关注神经-免疫-微生物群的相互作用，以及最近对微生物组对人类健康的不同影响的机械理解方面的进展。最后，我们对微生物群-肠道-大脑研究的未来提出了前瞻性的观点，这可能最终揭示出治疗受微生物群和大脑之间复杂联系影响的各种疾病的新途径。
In the past two decades, work on the microbiota-gut-brain axis has led to a renewed appreciation for the interconnectedness between body systems in both clinical and scientific circles. In the USA alone, millions of adults are burdened with non-communicable chronic diseases whose putative etiologies were previously thought to be restricted to either the gut or brain, such as inflammatory bowel disease, irritable bowel syndrome, Parkinson’s and Alzheimer’s disease, and autism spectrum disorder. However, the recent explosion of research into the impacts of the gut microbiome on diverse aspects of human health has revealed the potentially critical importance of reciprocal interactions between the gut microbiota, the immune system, and the brain in diverse diseases and disorders. In this review, we revisit the history of gut-brain interactions in science and medicine, which dates back to at least the eighteenth century, and outline how concepts in this field have shifted and evolved across eras. Next, we highlight the modern resurgence of gut-brain axis research, focusing on neuro-immune-microbiota interactions and recent progress towards a mechanistic understanding of the diverse impacts of the microbiome on human health. Finally, we offer a forward-looking perspective on the future of microbiota-gut-brain research, which may eventually reveal new paths towards the treatment of diverse diseases influenced by the complex connections between the microbiota and the brain.
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影响因子：
82.9
作者：
Benakis C;Brea D;Caballero S;Faraco G;Moore J;Murphy M;Sita G;Racchumi G;Ling L;Pamer EG;Iadecola C;Anrather J
通讯作者：
Anrather J
影响因子：
4.3
作者：
Bonaz B;Bazin T;Pellissier S
通讯作者：
Pellissier S
影响因子：
30.5
作者：
Alves de Lima K;Rustenhoven J;Da Mesquita S;Wall M;Salvador AF;Smirnov I;Martelossi Cebinelli G;Mamuladze T;Baker W;Papadopoulos Z;Lopes MB;Cao WS;Xie XS;Herz J;Kipnis J
通讯作者：
Kipnis J
DOI：
10.5501/wjv.v1.i4.108
发表时间：
2012-08-12
期刊：
World journal of virology
影响因子：
--
作者：
Baicus, Anda
通讯作者：
Baicus, Anda
影响因子：
4
作者：
Friedland, Robert P.
通讯作者：
Friedland, Robert P.