Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases.
Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases.
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DOI：
10.1155/2016/4234061
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发表时间：
2016
影响因子：
--
通讯作者：
Feng Y
中科院分区：
文献类型：
--
作者：
Li S;Hong M;Tan HY;Wang N;Feng Y
氧化应激和炎症在肝病发展中的关键作用几十年来一直被揭示和强调。从脂肪变性到纤维化、肝硬变和肝癌、肝脏氧化应激和炎症都持续存在，并参与了这一病理进展过程。值得注意的是，越来越多的证据表明，氧化应激与炎症密切相关，它们被认为是在各种病理条件下同时存在并相互作用的重要伙伴，形成了恶性循环，加剧了肝脏疾病。阐明氧化应激与炎症的相互作用，为开展治疗干预提供新的方向和靶点具有重要意义。本文就氧化应激和炎症在多种肝病中的调节和相互依赖关系作一综述。除了经典的介质和信号，特别强调免疫抑制，氧化应激和炎症的潜在联系，为肝病的治疗提供新的灵感。此外，由于抗氧化和抗炎已被广泛尝试作为治疗肝病的策略，本文对通过调节氧化应激和炎症共同保护肝脏免受损伤的中草药及其衍生化合物的应用进行了综述和讨论。
The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. From steatosis to fibrosis, cirrhosis and liver cancer, hepatic oxidative stress, and inflammation are sustained and participated in this pathological progressive process. Notably, increasing evidences showed that oxidative stress and inflammation are tightly related, which are regarded as essential partners that present simultaneously and interact with each other in various pathological conditions, creating a vicious cycle to aggravate the hepatic diseases. Clarifying the interaction of oxidative stress and inflammation is of great importance to provide new directions and targets for developing therapeutic intervention. Herein, this review is concerned with the regulation and interdependence of oxidative stress and inflammation in a variety of liver diseases. In addition to classical mediators and signaling, particular emphasis is placed upon immune suppression, a potential linkage of oxidative stress and inflammation, to provide new inspiration for the treatment of liver diseases. Furthermore, since antioxidation and anti-inflammation have been extensively attempted as the strategies for treatment of liver diseases, the application of herbal medicines and their derived compounds that protect liver from injury via regulating oxidative stress and inflammation collectively were reviewed and discussed.
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