Amygdala functional connectivity mediates the association between catastrophizing and threat-safety learning in youth with chronic pain.
Amygdala functional connectivity mediates the association between catastrophizing and threat-safety learning in youth with chronic pain.
复制标题
DOI：
10.1097/j.pain.0000000000002410
复制
发表时间：
2022-04-01
期刊：
影响因子：
7.4
通讯作者：
Simons LE
中科院分区：
文献类型：
--
作者：
Timmers I;López-Solà M;Heathcote LC;Heirich M;Rush GQ;Shear D;Borsook D;Simons LE
There is a need to identify brain connectivity alterations predictive of transdiagnostic processes that may confer vulnerability for affective symptomology. Here, we tested whether amygdala resting-state functional connectivity (rsFC) mediated the relationship between catastrophizing (negative threat appraisals; predicting poorer functioning) and altered threat-safety discrimination learning (critical to flexibly adapt to new and changing environments) in adolescents with persistent pain. We examined amygdala rsFC in 46 youth with chronic pain and 29 healthy peers (age M=15.8, SD=2.9; 64 females), and its relationship with catastrophizing and threat-safety learning. We used a developmentally appropriate threat-safety learning paradigm and performed amygdala seed-based rsFC and whole-brain mediation analyses. Patients exhibited enhanced connectivity between left amygdala and right supramarginal gyrus (cluster-level p-FDR < .05), while right amygdala rsFC showed no group differences. Only in patients, elevated catastrophizing was associated with facilitated threat-safety learning (CS+>CS−; rp = .49, p = .001). Furthermore, in patients, elevated catastrophizing was associated with reduced left amygdala connectivity with supramarginal gyrus/parietal operculum, and increased left amygdala connectivity with hippocampus, dorsal striatum, paracingulate and motor regions (p < .001). And, blunted left amygdala rsFC with right supramarginal gyrus/parietal operculum mediated the association between catastrophizing and threat-safety learning (p < .001). To conclude, rsFC between left amygdala (a core emotion hub) and inferior parietal lobe (involved in appraisal and integration of bodily signals, and attentional reorienting) explains associations between daily-life relevant catastrophizing and threat-safety learning. Findings provide a putative model for understanding pathophysiology involved in core psychological processes that cut across diagnoses, including disabling pain, and are relevant for their etiology.
登录
查看更多内容
影响因子：
10.6
作者：
Grillon, C
通讯作者：
Grillon, C
影响因子：
3.1
作者：
CHAVES, JF;BROWN, JM
通讯作者：
BROWN, JM
影响因子：
3.1
作者：
Caspers, Svenja;Eickhoff, Simon B.;Amunts, Katrin
通讯作者：
Amunts, Katrin
影响因子：
17.7
作者：
Frazier, JA;Chiu, SF;Biederman, J
通讯作者：
Biederman, J
影响因子：
14.5
作者：
Hashmi, Javeria A.;Baliki, Marwan N.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania