Repetition of verbal fluency task attenuates the hemodynamic activation in the left prefrontal cortex: Enhancing the clinical usefulness of near-infrared spectroscopy.
Repetition of verbal fluency task attenuates the hemodynamic activation in the left prefrontal cortex: Enhancing the clinical usefulness of near-infrared spectroscopy.
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DOI：
10.1371/journal.pone.0193994
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Shirakawa O
中科院分区：
文献类型：
--
作者：
Kawakubo Y;Yanagi M;Tsujii N;Shirakawa O
近红外光谱（NIRS）在日本的临床精神病学环境中的应用中，采用包括“转换”（有效转换到新词子类别的能力）以评估音素流畅性的音素语言流畅性测试（VFT）来捕获前额叶皮层（PFC）中的疾病特异性血流动力学变化。在本研究中，为了扩展该测试的特定功能，重复VFT以检查20名健康男性的NIRS测量中的激活变化。在没有任务表现变化的情况下，通过重复任务，VFT诱导的血流动力学激活在左侧PFC中显著减弱。这些结果表明，左侧PFC参与VFT的处理。此外，有可能使用这种重复来扩展当前VFT，以提供对左PFC的更灵敏的检查，其功能障碍已在几种精神疾病中被报道，如重度抑郁症、双相情感障碍和精神分裂症。
In applications of near-infrared spectroscopy (NIRS) in clinical psychiatry settings in Japan, a phonemic verbal fluency test (VFT) that includes “switching” (the ability to shift efficiently to a new word subcategory) to assess phonemic fluency is employed to capture disease-specific hemodynamic changes in the prefrontal cortex (PFC). In this study, to extend the specific features of this test, the VFT was repeated to examine an activation change in NIRS measurements in 20 healthy males. Without task performance change, the hemodynamic activation induced by the VFT was significantly attenuated in the left PFC through repetition of the task. These findings suggest that the left PFC is involved in processing of the VFT. Further, it may be possible to extend the current VFT using this repetition to provide a more sensitive examination of the left PFC, whose dysfunction has been reported in several psychiatric diseases such as major depression, bipolar disorder, and schizophrenia.
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DOI：
10.1073/pnas.95.3.906
发表时间：
1998-02-03
影响因子：
11.1
作者：
Gabrieli, JDE;Poldrack, RA;Desmond, JE
通讯作者：
Desmond, JE
DOI：
10.1016/j.cortex.2012.05.022
发表时间：
2013-05
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Barbey AK;Koenigs M;Grafman J
通讯作者：
Grafman J
影响因子：
5.3
作者：
Katzev, Michael;Tuescher, Oliver;Kaller, Christoph P.
通讯作者：
Kaller, Christoph P.
影响因子：
3.7
作者：
Sayala, S;Sala, JB;Courtney, SM
通讯作者：
Courtney, SM
影响因子：
8.2
作者：
Goghari, Vina M.;Sponheim, Scott R.;MacDonald, Angus W., III
通讯作者：
MacDonald, Angus W., III