The functional neuroanatomy of symptom dimensions in schizophrenia: a qualitative and quantitative review of a persistent question.
The functional neuroanatomy of symptom dimensions in schizophrenia: a qualitative and quantitative review of a persistent question.
复制标题
DOI：
10.1016/j.neubiorev.2009.09.004
复制
发表时间：
2010-03
影响因子：
8.2
通讯作者：
MacDonald, Angus W., III
中科院分区：
文献类型：
--
作者：
Goghari, Vina M.;Sponheim, Scott R.;MacDonald, Angus W., III
关键词：
理解精神分裂症的基本目标之一是将可观察到的症状与潜在的不可观察的病理生理联系起来。鉴于医学影像学的最新进展，研究人员越来越多地研究脑行为关系，以更好地了解精神分裂症中阴性、阳性和紊乱症状的神经基质。本综述集中于25项与任务相关的功能性磁共振成像研究，发现特定症状维度与区域大脑活动之间有意义的小到中度关联。阴性症状与腹外侧前额叶皮层和腹侧纹状体功能有关。阳性症状，特别是迫害意念，与内侧前额皮质、杏仁核和海马体/海马体旁区的功能有关。紊乱症状虽然较少被评估，但与背外侧前额皮质的功能有关。令人惊讶的是，没有一个症状域与颞中上区有一致的关系。虽然实验设计和报告标准的一些调整可以促进这项工作，但目前的神经成像方法似乎提供了精神分裂症明显症状与脑功能障碍之间的一些一致的联系。
One of the fundamental goals in understanding schizophrenia is linking the observable symptoms to the underlying unobservable pathophysiology. Given recent advances in medical imaging, researchers are increasingly investigating brain-behavior relationships to better understand the neural substrates of negative, positive, and disorganization symptoms in schizophrenia. This review focused on 25 task-related functional magnetic resonance imaging studies and found meaningful small to moderate associations between specific symptom dimensions and regional brain activity. Negative symptoms were related to the functioning of the ventrolateral prefrontal cortex and ventral striatum. Positive symptoms, particularly persecutory ideation, were related to functioning of the medial prefrontal cortex, amygdala, and hippocampus/parahippocampal region. Disorganization symptoms, although less frequently evaluated, were related to functioning of the dorsolateral prefrontal cortex. Surprisingly, no symptom domain had a consistent relationship with the middle or superior temporal regions. While a number of adaptations in experimental design and reporting standards can facilitate this work, current neuroimaging approaches appear to provide a number of consistent links between the manifest symptoms of schizophrenia and brain dysfunction.
登录
查看更多内容
影响因子：
4.5
作者：
Grube, BS;Bilder, RM;Goldman, RS
通讯作者：
Goldman, RS
影响因子：
3.3
作者：
Buxton, RB;Wong, EC;Frank, LR
通讯作者：
Frank, LR
影响因子：
16.2
作者：
Breiter, HC;Aharon, I;Shizgal, P
通讯作者：
Shizgal, P
影响因子：
3.4
作者：
Fu, CHY;Abel, KM;McGuire, PK
通讯作者：
McGuire, PK
影响因子：
--
作者：
Gur, Raquel E.;Loughead, James;Gur, Ruben C.
通讯作者：
Gur, Ruben C.