The mosquito vectors that sustained malaria transmission during the Magude project despite the combined deployment of indoor residual spraying, insecticide-treated nets and mass-drug administration.
The mosquito vectors that sustained malaria transmission during the Magude project despite the combined deployment of indoor residual spraying, insecticide-treated nets and mass-drug administration.
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尽管室内残留喷涂，经杀虫剂处理的网和大规模药物给药，但在Magude项目期间持续疟疾传播的蚊子向量。
DOI：
10.1371/journal.pone.0271427
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Paaijmans, Krijn P.
中科院分区：
文献类型：
--
作者：
Montoya, Lucia Fernandez;Marti-Soler, Helena;Maquina, Mara;Comiche, Kiba;Cuamba, Inocencia;Alafo, Celso;Koekemoer, Lizette L.;Sherrard-Smith, Ellie;Bassat, Quique;Galatas, Beatriz;Aide, Pedro;Cuamba, Nelson;Jotamo, Dulcisaria;Saute, Francisco;Paaijmans, Krijn P.
“马古德项目”的目的是在莫桑比克南部马古德县阻断当地疟疾传播，但未能成功，该项目采用了一整套综合干预措施，包括室内滞留喷洒、仅含拟除虫菊酯的长效驱虫蚊帐和大规模药物管理。在这里，我们提供了详细的信息，媒介物种，持续疟疾传播，他们与疟疾发病率和行为，以及他们的顺从性实施控制干预措施。在2015年5月至2017年10月期间，每月在Magude区的六个哨点收集蚊子，使用CDC室内和室外灯陷阱。阿拉伯按蚊是该项目的主要媒介，而按蚊是该项目的主要媒介。funestus s.s.，一个. merus，一枝枝兰（An. parensis和An.鳞片可能起了次要作用。在莫桑比克南部，后两个物种以前从未被发现对恶性疟原虫呈阳性。在整个项目中，干预措施成功地降低了所有物种的载体子孢子率。IRS是有效的控制安。富内斯图斯公司和一个. parensis，这几乎消失后，其第一次实施，但在控制安。阿拉伯的。尽管次优使用，LLIN可能提供了显着的保护，对安。arabiensis和安.当人们躺在床上时，它们主要在室内寻找主人。在马古德项目期间，在长效驱虫蚊帐和MDA的基础上增加IRS可能会增加疟疾病媒控制的价值。今后在该地区消除疟疾的努力可受益于：一）增加长效驱虫蚊帐的使用，二）使用长效IRS产品，以抵消在传播高峰期结束时观察到的病媒密度增加，三）扩大MDA覆盖面，以减少人类感染的可能性。然而，可能需要针对在室内滞留喷雾杀虫剂和长效驱虫蚊帐中存活下来的病媒采取额外的干预措施，以便在当地消除疟疾。
The “Magude project” aimed but failed to interrupt local malaria transmission in Magude district, southern Mozambique, by using a comprehensive package of interventions, including indoor residual spraying (IRS), pyrethroid-only long-lasting insecticide treated nets (LLINs) and mass-drug administration (MDA). Here we present detailed information on the vector species that sustained malaria transmission, their association with malaria incidence and behaviors, and their amenability to the implemented control interventions. Mosquitoes were collected monthly between May 2015 and October 2017 in six sentinel sites in Magude district, using CDC light traps both indoors and outdoors. Anopheles arabiensis was the main vector during the project, while An. funestus s.s., An. merus, An. parensis and An. squamosus likely played a secondary role. The latter two species have never previously been found positive for Plasmodium falciparum in southern Mozambique. The intervention package successfully reduced vector sporozoite rates in all species throughout the project. IRS was effective in controlling An. funestus s.s. and An. parensis, which virtually disappeared after its first implementation, but less effective at controlling An. arabiensis. Despite suboptimal use, LLINs likely provided significant protection against An. arabiensis and An. merus that sought their host largely indoors when people where in bed. Adding IRS on top of LLINs and MDA likely added value to the control of malaria vectors during the Magude project. Future malaria elimination attempts in the area could benefit from i) increasing the use of LLINs, ii) using longer-lasting IRS products to counteract the increase in vector densities observed towards the end of the high transmission season, and iii) a higher coverage with MDA to reduce the likelihood of human infection. However, additional interventions targeting vectors that survive IRS and LLINs by biting outdoors or indoors before people go to bed, will be likely needed to achieve local malaria elimination.
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影响因子：
3.2
作者：
Abílio AP;Kampango A;Armando EJ;Gudo ES;das Neves LCB;Parreira R;Sidat M;Fafetine JM;de Almeida APG
通讯作者：
de Almeida APG
非洲瞬间蚊子（双翅目：Culicidae）对疟疾控制程序的形态鉴定的重要性。
影响因子：
3
作者：
Erlank E;Koekemoer LL;Coetzee M
通讯作者：
Coetzee M
影响因子：
2.1
作者：
Fornadel, Christen M.;Norris, Laura C.;Norris, Douglas E.
通讯作者：
Norris, Douglas E.
影响因子：
3
作者：
Burke, Ashley;Dahan-Moss, Yael;Brooke, Basil
通讯作者：
Brooke, Basil
影响因子：
3
作者：
Dery DB;Brown C;Asante KP;Adams M;Dosoo D;Amenga-Etego S;Wilson M;Chandramohan D;Greenwood B;Owusu-Agyei S
通讯作者：
Owusu-Agyei S