Patterns and seasonality of malaria transmission in the forest-savannah transitional zones of Ghana.
Patterns and seasonality of malaria transmission in the forest-savannah transitional zones of Ghana.
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DOI：
10.1186/1475-2875-9-314
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发表时间：
2010-11-07
期刊：
影响因子：
3
通讯作者：
Owusu-Agyei S
中科院分区：
文献类型：
--
作者：
Dery DB;Brown C;Asante KP;Adams M;Dosoo D;Amenga-Etego S;Wilson M;Chandramohan D;Greenwood B;Owusu-Agyei S
了解当地的疟疾传播模式以及季节对传播的影响对于规划和评估疟疾干预措施至关重要。因此，2003年11月至2005年11月在加纳森林-草原过渡带（金坦波）进行了昆虫学调查，为药物和疫苗试验做准备。两年期间（2003 年 11 月至 2005 年 11 月），共从 919 个诱捕器中捕获了 23,406 只蚊子：54.3% 为库蚊，36.2% 为按蚊，9.4% 为冈比亚按蚊。冈比亚按蚊和福氏按蚊的恶性疟原虫感染率分别为 4.7% 和 1.5%。第一年（2003年11月至2004年10月）昆虫学接种率（EIR）为每人每年269次感染性叮咬，次年（2004年11月至2005年11月）为231次。聚合酶链反应 (PCR) 分析仅检测到冈比亚按蚊 s.s.。在雨季对 19 只蚊子进行了 PCR 检测； 16个是S分子形式，2个M分子形式和1个混合形式(S/M)。在旱季，测试了十六只蚊子； 11 种 S 分子形式、2 种 M 分子形式和 3 种 S/M 杂种。击倒抗性(kdr)基因型F(R)的频率为0.60。金坦波地区疟疾病媒的动态和季节性丰度受到微生态、降雨和温度模式的影响。两年（2004 年和 2005 年）之间的传播模式没有显着差异，冈比亚按蚊和福内斯按蚊均被确定为有效媒介。 EIR 估计 2004/2005 年每人每年被感染的叮咬次数为 231 至 269 次。该研究提供的信息将有助于规划加强疟疾控制活动以及评估加纳中部地带疟疾干预措施的影响。
Knowledge of the local pattern of malaria transmission and the effect of season on transmission is essential for the planning and evaluation of malaria interventions. Therefore, entomological surveys were carried out in the forest-savannah transitional belt of Ghana (Kintampo) from November 2003 to November 2005 in preparation for drug and vaccine trials. A total of 23,406 mosquitoes were caught from 919 traps over the two-year period (November 2003 to November 2005): 54.3% were Culicines, 36.2% Anopheles funestus, and 9.4% Anopheles gambiae. Infection rates with Plasmodium falciparum were 4.7% and 1.5% for Anopheles gambiae and Anopheles funestus, respectively. Entomological inoculation rates (EIRs) were 269 infective bites per person per year in the first year (November 2003-October 2004) and 231 the following year (November 2004-November 2005). Polymerase Chain Reaction (PCR) analysis detected only Anopheles gambiae s.s. Nineteen mosquitoes were tested by PCR in the wet season; 16 were S-molecular form, 2 M-molecular form and 1 hybrid (S/M). In the dry season, sixteen mosquitoes were tested; 11 S-molecular form, 2 M-molecular form and 3 S/M hybrids. The frequency of knock down resistance (kdr) genotypes F(R) was 0.60. The dynamics and seasonal abundance of malaria vectors in the Kintampo area was influenced by micro-ecology, rainfall and temperature patterns. Transmission patterns did not differ significantly between the two years (2004 and 2005) and both Anopheles gambiae and Anopheles funestus were identified as effective vectors. EIR estimates in 2004/2005 were between 231 and 269 infective bites per person per year. The information provided by the study will help in planning intensified malaria control activities as well as evaluating the impact of malaria interventions in the middle belt of Ghana.
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影响因子：
2.6
作者：
Fanello, C;Petrarca, V;Coluzzi, M
通讯作者：
Coluzzi, M
DOI：
10.1016/j.trstmh.2003.10.006
发表时间：
2004-07-01
影响因子：
2.2
作者：
Masendu, HT;Hunt, RH;Coetzee, M
通讯作者：
Coetzee, M
影响因子：
2.6
作者：
Ranson, H;Paton, MG;Collins, FH
通讯作者：
Collins, FH
影响因子：
3
作者：
Owusu-Agyei S;Asante KP;Adjuik M;Adjei G;Awini E;Adams M;Newton S;Dosoo D;Dery D;Agyeman-Budu A;Gyapong J;Greenwood B;Chandramohan D
通讯作者：
Chandramohan D
影响因子：
2.6
作者：
Black, WC;Lanzaro, GC
通讯作者：
Lanzaro, GC