Lithium decreases plasma adiponectin levels in bipolar depression.
Lithium decreases plasma adiponectin levels in bipolar depression.
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锂可降低双相抑郁症患者的血浆脂联素水平。
DOI：
10.1016/j.neulet.2014.02.005
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发表时间：
2014
影响因子：
2.5
通讯作者：
Teixeira,AntonioLucio
中科院分区：
文献类型：
--
作者：
Soeiro-de-Souza,MarcioGerhardt;Gold,PhilipW;Brunoni,AndreR;deSousa,RafaelT;Zanetti,MarcusV;Carvalho,AndreF;Gattaz,WagnerFarid;Machado-Vieira,Rodrigo;Teixeira,AntonioLucio
锂作为双相情感障碍（BD）的一线治疗药物，与显著的体重增加有关，但这种现象背后的机制尚不清楚。有人认为，脂肪因子的产生/释放的变化可能与此有关。脂肪因子是由脂肪组织分泌的具有抗炎（脂联素）和促炎（瘦素、抵抗素）特性的分子。在基线和锂治疗6周后，对25例急性抑郁双相障碍患者（88%未用药，68%未治疗）以及23例年龄匹配的健康对照进行脂联素、抵抗素和瘦素评估。采用21项汉密尔顿抑郁评定量表评估抑郁严重程度。锂单药治疗后脂联素水平明显下降，而抵抗素和瘦素水平在随访期间保持稳定。与对照组相比，双相障碍患者抑郁发作期间的脂肪因子水平没有差异。缓解者的预处理瘦素水平较高，而抵抗素水平的变化与锂治疗后抑郁症状的改善呈负相关。我们的研究结果揭示了这一病理生理过程，它可能与代谢综合征、炎症和其他双相障碍的医学合并症有关。
Lithium, a first line treatment for bipolar disorder (BD), has been associated with significant weight gain, but the mechanisms underlying this phenomenon are still unclear. It has been suggested that changes in production/release of adipokines – molecules secreted by adipose tissue presenting anti-inflammatory (adiponectin) and pro-inflammatory (leptin, resistin) properties – might be implicated. Adiponectin, resistin and leptin were assessed in 25 acutely depressed BD individuals (88% medication-free and 68% treatment-naive) at baseline and after 6 weeks of lithium therapy, and in 23 healthy controls matched by age. The 21-item Hamilton Depression Rating Scale was used to assess depression severity. Levels of adiponectin significantly decreased after lithium monotherapy, while the levels of resistin and leptin remained stable after the follow-up period. Adipokine levels during depressive episodes in BD did not differ compared to controls. Pretreatment levels of leptin were higher in remitters and changes in resistin levels were negatively correlated to improvement of depressive symptoms with lithium. Our findings shed light in this pathophysiological process, which might be associated with metabolic syndrome, inflammation and other medical comorbidities in BD.
X 射线诱导 C3H 小鼠胚胎来源细胞系的转化。
影响因子：
11.2
作者：
Margaret Terzaghi;J. Little
通讯作者：
J. Little
甲状腺激素在细胞培养中 X 射线诱导的肿瘤转化中的关键作用。
DOI：
10.1073/pnas.78.9.5708
发表时间：
1981
影响因子：
11.1
作者：
Guernsey,DL;Borek,C;Edelman,IS
通讯作者：
Edelman,IS