Surface-Based Falff: A Potential Novel Biomarker for Prediction of Radiation Encephalopathy in Patients With Nasopharyngeal Carcinoma.
Surface-Based Falff: A Potential Novel Biomarker for Prediction of Radiation Encephalopathy in Patients With Nasopharyngeal Carcinoma.
复制标题
基于表面的 Falff 是预测鼻咽癌患者放射性脑病的潜在新型生物标志物
DOI：
10.3389/fnins.2021.692575
复制
发表时间：
2021
影响因子：
4.3
通讯作者：
Liao WH
中科院分区：
文献类型：
--
作者：
Zhang YM;Kang YF;Zeng JJ;Li L;Gao JM;Liu LZ;Shi LR;Liao WH
放射性脑病（RE）是鼻咽癌（NPC）患者接受放射治疗（RT）的重要潜在并发症，可影响患者的生活质量。然而，尚未建立症状前RE的功能性成像生物标志物。本研究旨在评估辐射诱导的灰质功能改变，并探讨低频波动分数振幅（fALFF）作为预测或诊断鼻咽癌患者RE的影像学生物标志物。共检查了60例NPC患者，21例在RT前队列中，39例在RT后队列中。根据随访中RE的发生率，将RT后队列中的患者进一步分为两个亚组：RT后非RE（n = 21）和RT后随访中证实RE（n = 18）。基于表面和基于体积的fALFF用于检测辐射诱导的功能改变。然后采用功能衍生特征构建RE诊断的预测模型。我们观察到，基于表面的fALFF可以灵敏地检测颞内脑区（如海马和上级颞回）以及颞外脑区（如颞叶和前额叶）辐射诱导的功能改变;然而，使用基于体积的fALFF没有观察到显著的组间差异。未观察到fALFF与同侧颞叶辐射剂量之间的显著相关性。支持向量机（SVM）分析显示，基于表面的fALFF在双边上级颞回和左颞叶表现出令人印象深刻的性能（准确率= 80.49%），在确定患者可能发展为RE。我们的结论是，基于表面的fALFF可以作为一个敏感的成像生物标志物在RE的预测。
Radiation encephalopathy (RE) is an important potential complication in patients with nasopharyngeal carcinoma (NPC) who undergo radiotherapy (RT) that can affect the quality of life. However, a functional imaging biomarker of pre-symptomatic RE has not yet been established. This study aimed to assess radiation-induced gray matter functional alterations and explore fractional amplitude of low-frequency fluctuation (fALFF) as an imaging biomarker for predicting or diagnosing RE in patients with NPC. A total of 60 patients with NPC were examined, 21 in the pre-RT cohort and 39 in the post-RT cohort. Patients in the post-RT cohort were further divided into two subgroups according to the occurrence of RE in follow-up: post-RT non−RE (n = 21) and post-RT REproved infollow−up (n = 18). Surface-based and volume-based fALFF were used to detect radiation-induced functional alterations. Functional derived features were then adopted to construct a predictive model for the diagnosis of RE. We observed that surface-based fALFF could sensitively detect radiation-induced functional alterations in the intratemporal brain regions (such as the hippocampus and superior temporal gyrus), as well as the extratemporal regions (such as the insula and prefrontal lobe); however, no significant intergroup differences were observed using volume-based fALFF. No significant correlation between fALFF and radiation dose to the ipsilateral temporal lobe was observed. Support vector machine (SVM) analysis revealed that surface-based fALFF in the bilateral superior temporal gyri and left insula exhibited impressive performance (accuracy = 80.49%) in identifying patients likely to develop RE. We conclude that surface-based fALFF may serve as a sensitive imaging biomarker in the prediction of RE.
登录
查看更多内容
影响因子：
4.7
作者：
Greene-Schloesser D;Robbins ME;Peiffer AM;Shaw EG;Wheeler KT;Chan MD
通讯作者：
Chan MD
影响因子：
15.9
作者：
Beera KG;Li YQ;Dazai J;Stewart J;Egan S;Ahmed M;Wong CS;Jaffray DA;Nieman BJ
通讯作者：
Nieman BJ
初治晚年抑郁症患者的异常局部自发神经活动：一项静息态功能磁共振成像研究
DOI：
10.1016/j.pnpbp.2012.07.004
发表时间：
2012-12-03
影响因子：
5.6
作者：
Liu, Feng;Hu, Maorong;Chen, Huafu
通讯作者：
Chen, Huafu
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
鼻咽癌放疗后放疗引起的皮质厚度异常
DOI：
10.1016/j.nicl.2017.02.025
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Lin J;Lv X;Niu M;Liu L;Chen J;Xie F;Zhong M;Qiu S;Li L;Huang R
通讯作者：
Huang R