Association of dental and periodontal status with bisphosphonate-related osteonecrosis of the jaws. A retrospective case controlled study.
Association of dental and periodontal status with bisphosphonate-related osteonecrosis of the jaws. A retrospective case controlled study.
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DOI：
10.5114/aoms.2014.40738
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发表时间：
2014-02-24
期刊：
影响因子：
--
通讯作者：
Kos M
中科院分区：
文献类型：
--
作者：
Kos M
评估口腔卫生、龋齿和牙周状况与双磷酸盐相关颌骨坏死的关系。对 81 名骨转移肿瘤患者进行的回顾性病例对照研究。使用口腔卫生指数、腐烂、缺失、补牙、社区牙周治疗需求指数和残留牙周骨对 29 名骨坏死患者和 52 名接受双磷酸盐治疗的对照进行比较。零假设指出，患有和不患有骨坏死的患者之间的口腔健康参数没有差异。采用Student's t检验或Mann-Whitney秩和检验和χ2检验比较各组间上述变量均值的差异。 p 值 ≤ 0.05 被认为是显着的。口腔卫生较差（OHI 1.94 vs. 1.32；p = 0.065），更严重的龋齿（DMFT 26.85 vs. 22.87；p = 0.05），以及更严重的牙周病（CPITN：= 0：21.05% vs. 42.51%；= 1 13.16% vs. 7.29%；=与对照组相比，2：0% vs. 15.38%；= 3：65.79% vs. 28.34%；= 4：0% vs. 6.48%，残留牙周骨 73.1% vs. 80.51%；p = 0,001）。晚期龋齿或牙周病需要手术干预，这直接导致骨坏死的发展。牙科和牙周疾病可导致双磷酸盐相关的颌骨坏死。应为接受双磷酸盐治疗的肿瘤患者提供预防性护理，以减少牙菌斑、牙结石、龋齿和牙周病。
To assess the association of oral hygiene, dental caries, and periodontal status with bisphosphonate-related osteonecrosis of the jaws. A retrospective case-control study on 81 patients treated for neoplasms with bone metastases. Twenty-nine patients with bone necrosis and 52 controls treated with bisphosphonates were compared using the Oral Hygiene Index, Decay, Missing, Filled Teeth, Community Periodontal Index of Treatment Needs, and Residual Periodontal Bone. The null hypothesis stated that there was no difference in parameters of oral health between patients with and without bone necrosis. Differences of means of above-mentioned variables were compared between the groups with Student's t-test or Mann-Whitney rank sum test and χ2 test. Value of p ≤ 0.05 was considered significant. Poorer oral hygiene (OHIs 1.94 vs. 1.32; p = 0.065), more advanced dental caries (DMFT 26.85 vs. 22.87; p = 0.05), and more advanced periodontal disease (CPITN: = 0: 21.05% vs. 42.51%; = 1 13.16% vs. 7.29%; = 2: 0% vs. 15.38%; = 3: 65.79% vs. 28.34%; = 4: 0% vs. 6.48%, Residual periodontal bone 73.1% vs. 80.51%; p = 0,001) were characteristic of patients with bisphosphonate related jaw necrosis when compared with control group. An advanced dental caries or periodontal disease required surgical intervention which directly contributed to the development of the bone necrosis. Dental and periodontal disease can lead to bisphosphonate-related osteonecrosis of the jaw. Oncologic patients treated with bisphosphonates should be offered preventive care to reduce dental plaque, calculus, dental caries, and periodontal disease.
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DOI：
10.1111/j.1749-6632.2010.05835.x
发表时间：
2011-01-01
期刊：
BISPHOSPHONATES AND OSTEONECROSIS OF THE JAW
影响因子：
--
作者：
Landesberg, Regina;Woo, Victoria;Raghavan, Srikala
通讯作者：
Raghavan, Srikala
影响因子：
45.3
作者：
Bamias, A;Kastritis, E;Dimopoulos, MA
通讯作者：
Dimopoulos, MA
影响因子：
4.8
作者：
Elad, Sharon;Thierer, Todd;Meyerowitz, Cyril
通讯作者：
Meyerowitz, Cyril
DOI：
10.1007/s10856-005-0625-x
发表时间：
2005-04-01
影响因子：
3.7
作者：
Ganguli, A;Steward, C;Grant, MH
通讯作者：
Grant, MH
影响因子：
6.2
作者：
Hoff, Ana O.;Toth, Bela B.;Hortobagyi, Gabriel N.
通讯作者：
Hortobagyi, Gabriel N.