Probiotic properties of Oxalobacter formigenes: an in vitro examination.
Probiotic properties of Oxalobacter formigenes: an in vitro examination.
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DOI:
10.1007/s00203-016-1272-y
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发表时间:
2016-12
影响因子:
2.8
通讯作者:
Knight, John
中科院分区:
文献类型:
--
作者:
Ellis, Melissa L.;Dowell, Alexander E.;Li, Xingsheng;Knight, John
Oxalobacter formigenes (O. formigenes) is a nonpathogenic, Gram-negative, obligate anaerobic bacterium that commonly inhabits the human gut and degrades oxalate as its major energy and carbon source. Results from a case-controlled study suggested that lack of O. formigenes colonization is a risk factor for recurrent calcium oxalate stone formation. Hence, O. formigenes colonization may prove to be an efficacious method for limiting calcium oxalate stone risk. However, challenges exist in the preparation of O. formigenes as a successful probiotic due to it being an anaerobe with fastidious growth requirements. Here we examine in vitro properties expected of a successful probiotic strain. The data show that the Group 1 O. formigenes strain OxCC13 is sensitive to pH < 5.0, persists in the absence of oxalate, is aerotolerant, and survives for long periods when freeze-dried or mixed with yogurt. These findings highlight the resilience of this O. formigenes strain to some processes and conditions associated with the manufacture, storage and distribution of probiotic strains.
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DOI:
10.1016/j.juro.2015.08.070
发表时间:
2016-02
期刊:
The Journal of urology
影响因子:
--
作者:
Barnett C;Nazzal L;Goldfarb DS;Blaser MJ
通讯作者:
Blaser MJ
影响因子:
3.5
作者:
Celik, O. F.;O'Sullivan, D. J.
通讯作者:
O'Sullivan, D. J.
影响因子:
3.5
作者:
HEWITT, J;MORRIS, JG
通讯作者:
MORRIS, JG
影响因子:
4.4
作者:
DANIEL, SL;HARTMAN, PA;ALLISON, MJ
通讯作者:
ALLISON, MJ
影响因子:
13.6
作者:
Kaufman, David W.;Kelly, Judith P.;Cave, David R.
通讯作者:
Cave, David R.