Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior.
Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior.
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DOI：
10.1016/j.ynstr.2023.100603
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发表时间：
2024-03
影响因子：
5
通讯作者：
Homanics, Gregg E.
中科院分区：
文献类型：
--
作者：
Rice, Rachel C.;V. Gil, Daniela;Baratta, Annalisa M.;Frawley, Remy R.;Hill, Shirley Y.;Farris, Sean P.;Homanics, Gregg E.
慢性压力和酒精（乙醇）的使用是高度相关的，可以通过分子适应来改变个体的行为，这些分子适应不会改变DNA序列，而是改变基因表达。最近的大量研究发现，这些非基因组变化可以跨代传递，这可以部分解释在酒精使用障碍和其他压力相关神经精神疾病的全基因组关联研究中观察到的“缺失遗传性”。在这篇综述中，我们总结了慢性应激和乙醇暴露的非基因组遗传的分子和行为结果，以及可能引起这种遗传性的种系机制。在这样做的过程中，我们概述了进一步研究的必要性：（1）调查父亲，母亲和双亲非基因组慢性应激和乙醇相关遗传的个体种系机制;（2）合成和解剖跨代慢性应激和乙醇暴露;（3）确定导致酒精相关疾病风险的孕前乙醇暴露的跨代分子结果，以癌症为例。对压力和/或乙醇的跨代非基因组效应的详细了解将产生对祖先扰动对跨代疾病风险的影响的新见解，并发现改善人类健康的可行目标。
Chronic stress and alcohol (ethanol) use are highly interrelated and can change an individual’s behavior through molecular adaptations that do not change the DNA sequence, but instead change gene expression. A recent wealth of research has found that these nongenomic changes can be transmitted across generations, which could partially account for the “missing heritability” observed in genome-wide association studies of alcohol use disorder and other stress-related neuropsychiatric disorders. In this review, we summarize the molecular and behavioral outcomes of nongenomic inheritance of chronic stress and ethanol exposure and the germline mechanisms that could give rise to this heritability. In doing so, we outline the need for further research to: (1) Investigate individual germline mechanisms of paternal, maternal, and biparental nongenomic chronic stress- and ethanol-related inheritance; (2) Synthesize and dissect cross-generational chronic stress and ethanol exposure; (3) Determine cross-generational molecular outcomes of preconception ethanol exposure that contribute to alcohol-related disease risk, using cancer as an example. A detailed understanding of the cross-generational nongenomic effects of stress and/or ethanol will yield novel insight into the impact of ancestral perturbations on disease risk across generations and uncover actionable targets to improve human health.
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影响因子：
2.4
作者：
Bhaskaran M;Mohan M
通讯作者：
Mohan M
产后社会压力后，孕产妇行为中损害的代际积累。
影响因子：
3.7
作者：
Nephew BC;Carini LM;Sallah S;Cotino C;Alyamani RAS;Pittet F;Bradburn S;Murgatroyd C
通讯作者：
Murgatroyd C
影响因子：
4.4
作者：
Zaidan H;Ramaswami G;Golumbic YN;Sher N;Malik A;Barak M;Galiani D;Dekel N;Li JB;Gaisler-Salomon I
通讯作者：
Gaisler-Salomon I
影响因子：
4.1
作者：
Asimes A;Kim CK;Cuarenta A;Auger AP;Pak TR
通讯作者：
Pak TR
DOI：
10.1111/j.1530-0277.1988.tb00205.x
发表时间：
1988-06-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
ABEL, EL;LEE, JA
通讯作者：
LEE, JA