Closed-Loop, Multichannel Experimentation Using the Open-Source NeuroRighter Electrophysiology Platform.
Closed-Loop, Multichannel Experimentation Using the Open-Source NeuroRighter Electrophysiology Platform.
复制标题
DOI：
10.3389/fncir.2012.00098
复制
发表时间：
2012
影响因子：
3.5
通讯作者：
Potter SM
中科院分区：
文献类型：
--
作者：
Newman JP;Zeller-Townson R;Fong MF;Arcot Desai S;Gross RE;Potter SM
单神经元反馈控制技术，如电压钳和动态钳，使我们对离子通道、电化学信号和神经动力学的理解取得了许多进展。尽管商业上可用的多通道记录和刺激系统通常用于研究网络层面的神经处理，但它们对实时反馈的原生支持很少。我们开发了开源的neuroright多通道电生理硬件和软件平台，用于闭环多通道控制，重点是可访问性和低成本。neuroright允许64个刺激通道和记录，价格约为1万美元，并能与其他软件和硬件集成。在这里，我们对neuroright平台进行了实质性的改进，包括重新设计的桌面应用程序，允许任意刺激模式的新刺激子系统，用于访问数据流的低延迟数据服务器，以及用于创建闭环协议的新应用程序编程接口（API），该接口可以作为插件程序插入到neuroright中。这大大简化了复杂的实时实验的设计，而不会牺牲编译编程语言的功能和速度。在这里，我们详细介绍了作为一个独立应用程序的neuroright，它的插件API，以及一组广泛的案例研究，这些案例研究突出了该系统进行闭环、多通道接口实验的能力。
Single neuron feedback control techniques, such as voltage clamp and dynamic clamp, have enabled numerous advances in our understanding of ion channels, electrochemical signaling, and neural dynamics. Although commercially available multichannel recording and stimulation systems are commonly used for studying neural processing at the network level, they provide little native support for real-time feedback. We developed the open-source NeuroRighter multichannel electrophysiology hardware and software platform for closed-loop multichannel control with a focus on accessibility and low cost. NeuroRighter allows 64 channels of stimulation and recording for around US $10,000, along with the ability to integrate with other software and hardware. Here, we present substantial enhancements to the NeuroRighter platform, including a redesigned desktop application, a new stimulation subsystem allowing arbitrary stimulation patterns, low-latency data servers for accessing data streams, and a new application programming interface (API) for creating closed-loop protocols that can be inserted into NeuroRighter as plugin programs. This greatly simplifies the design of sophisticated real-time experiments without sacrificing the power and speed of a compiled programming language. Here we present a detailed description of NeuroRighter as a stand-alone application, its plugin API, and an extensive set of case studies that highlight the system’s abilities for conducting closed-loop, multichannel interfacing experiments.
登录
查看更多内容
DOI：
10.3389/fneng.2010.00005
发表时间：
2010
期刊：
Frontiers in neuroengineering
影响因子：
--
作者：
Desai SA;Rolston JD;Guo L;Potter SM
通讯作者：
Potter SM
DOI：
10.1109/tnsre.2006.875547
发表时间：
2006-06-01
影响因子：
4.9
作者：
Jackson, Andrew;Moritz, Chet T.;Fetz, Eberhard E.
通讯作者：
Fetz, Eberhard E.
影响因子：
8
作者：
Nelson, Timothy S.;Suhr, Courtney L.;Cook, Mark J.
通讯作者：
Cook, Mark J.
Meart：半生活的艺术家。
影响因子：
3.1
作者：
Bakkum, Douglas J;Gamblen, Philip M;Ben-Ary, Guy;Chao, Zenas C;Potter, Steve M
通讯作者：
Potter, Steve M
DOI：
10.3389/fneng.2011.00003
发表时间：
2011
期刊：
Frontiers in neuroengineering
影响因子：
--
作者：
Wallach A;Eytan D;Gal A;Zrenner C;Marom S
通讯作者：
Marom S