Facile synthesis of B,N-doped CQDs as versatile fluorescence probes for sensitive detection of cobalt ions in environmental water and biological samples
Facile synthesis of B,N-doped CQDs as versatile fluorescence probes for sensitive detection of cobalt ions in environmental water and biological samples
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轻松合成 B,N 掺杂 CQD 作为多功能荧光探针，用于灵敏检测环境水和生物样品中的钴离子
DOI：
10.1016/j.microc.2020.105888
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发表时间：
2021-04
影响因子：
4.8
通讯作者：
Chen Xiaoqing
中科院分区：
文献类型：
--
作者：
Zhao Xinyi;Wang Lumin;Liu Qi;Chen Miao;Chen Xiaoqing
碳量子点(CQD)作为多功能荧光探针同时检测各种样品中钴离子(Co2+)的研究仍未得到满足。本文以3-羧基苯基硼酸和乙二胺为前驱体，采用水热一步法合成了新型掺硼、掺氮碳量子点(B，N-CQD)。由于前驱体的独特性质，所得到的B，N-CQD对Co2+具有良好的识别能力、良好的生物相容性和较高的荧光量子产率(FLQY，64.8%)，这使得B，N-CQD成为灵敏检测Co2+的多功能荧光探针。该探针对Co2+的响应在0.5-10和10-2000 nm范围内呈线性关系，检测限(LOD)为0.52 nm。通过对污水、河水和自来水等实际水样中痕量Co2+的定量检测，评价了该探针实际应用的可行性。用该探针对人体尿液中的Co2+进行了检测，回收率在96%~104%之间，表明所建立的探针能够满足实际尿样检测的要求。此外，由于其良好的光稳定性和高信本底比，该探针被成功地用于监测A549细胞的荧光成像中的Co2+。这些结果表明，所设计的B，N-CQD是同时检测环境水和生物样品中Co2+的理想探针，这将扩大CQD的实际应用。
Fabrication of carbon quantum dots (CQDs) as versatile fluorescence probes for simultaneous detection of cobalt ion (Co2+) in various samples is still unmet. Herein, novel boron, nitrogen-doped carbon quantum dots (B,N-CQDs) were facile synthesizedviaone-step hydrothermal method, in which 3-carboxyphenylboronic acid and ethylenediamine were selected as precursors. Owing to the unique properties of the precursors, the obtained B,N-CQDs exhibited excellent recognition capability of Co2+, favorable biocompatibility, and high fluorescence quantum yield (FLQY, 64.8%), which enabled the B,N-CQDs as versatile fluorescence probes for sensitive detection of Co2+. The response of the probes to Co2+was linear in two ranges of 0.5–10 and 10–2000 nM with limit of detection (LOD) of 0.52 nM. Feasibility of practical application of the probes was assessed by quantitative detection of trace Co2+in real water samples including sewage water, river water and tap water. Furthermore, Co2+in human urine was detected by using the probes with recoveries between 96% and 104%, indicating that the established probes could meet the requirements of practical detection in urine samples. Besides, the probes were successfully applied to monitoring Co2+in A549 cellsviafluorescence imaging attributed to their excellent photostability and high signal-to-background ratio. All these results show that the designed B,N-CQDs are ideal probes for simultaneously detecting Co2+in environmental water and biological samples, which would expand the practical application of CQDs.
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