Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage.
Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage.
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循环 microRNA 作为潜在癌症生物标志物：优点和缺点
DOI：
10.1186/s13148-018-0492-1
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发表时间：
2018
影响因子：
5.7
通讯作者：
Xue L
中科院分区：
文献类型：
--
作者：
Wang H;Peng R;Wang J;Qin Z;Xue L
MicroRNA是内源性单链非编码小RNA分子，可分泌到循环中并稳定存在。它们在不同的生理和病理条件下通常表现出异常表达。近年来，差异表达的循环microRNA作为癌症筛查的潜在生物标志物受到关注。本文综述了循环microRNA在癌症诊断、肿瘤亚型分类、化疗或放疗耐药性监测和预后中的作用。此外，循环microRNA仍然存在几个问题，阻碍了它们在实际临床应用中的可靠性。未来的研究需要进一步阐明循环microRNA作为癌症临床诊断或预后的特异性和敏感性标志物的潜在应用。
MicroRNAs are endogenous single-stranded non-coding small RNA molecules that can be secreted into the circulation and exist stably. They usually exhibit aberrant expression under different physiological and pathological conditions. Recently, differentially expressed circulating microRNAs were focused on as potential biomarkers for cancer screening. We herein review the role of circulating microRNAs for cancer diagnosis, tumor subtype classification, chemo- or radio-resistance monitoring, and outcome prognosis. Moreover, circulating microRNAs still have several issues hindering their reliability for the practical clinical application. Future studies need to elucidate further potential application of circulating microRNAs as specific and sensitive markers for clinical diagnosis or prognosis in cancers.
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影响因子：
--
作者：
Baltzer PAT;Kapetas P;Marino MA;Clauser P
通讯作者：
Clauser P
影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
9.3
作者：
Eichelser, Corinna;Flesch-Janys, Dieter;Schwarzenbach, Heidi
通讯作者：
Schwarzenbach, Heidi
影响因子：
4.6
作者：
Hamam R;Ali AM;Alsaleh KA;Kassem M;Alfayez M;Aldahmash A;Alajez NM
通讯作者：
Alajez NM
影响因子：
1.8
作者：
Geva GA;Gielchinsky I;Aviv N;Max KEA;Gofrit ON;Gur-Wahnon D;Ben-Dov IZ
通讯作者：
Ben-Dov IZ