Sleep quality and architecture in quetiapine, risperidone, or never-treated schizophrenia patients.
Sleep quality and architecture in quetiapine, risperidone, or never-treated schizophrenia patients.
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喹硫平、利培酮或从未治疗过的精神分裂症患者的睡眠质量和结构。
DOI：
10.1097/jcp.0b013e31815a884d
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发表时间：
2007
影响因子：
2.9
通讯作者：
Kupfer,DavidJ
中科院分区：
文献类型：
--
作者：
Keshavan,MatcheriS;Prasad,KonasaleM;Montrose,DebraM;Miewald,JeanM;Kupfer,DavidJ
（Wilks Lambda= 0.59; F15= 3.14; P< 0.0000）。个体方差分析显示，与NNS组相比，QS组和RS组在床上的时间更多，睡眠维持减少，睡眠潜伏期延长，觉醒时间增加，但睡眠总时间无差异。与NNS组相比，QS组和RS组REM潜伏期略有延长，REM百分比降低。QS和RS组的第2阶段睡眠显著增加，而SWS降低。QS和RS组在任何视觉评分的睡眠测量方面没有差异（数据未显示）。个体ANCOVA显示了REM和δ计数（总数和平均值）的有趣组差异（表1）。事后比较显示，与NNS组相比，QS组的平均REM计数显著升高，但RS组与NNS组无差异。我们还检查了药物剂量和REM计数之间是否存在剂量效应关系。平均奎替鲁肽剂量为313.33 ± 228.71 mg，平均利培酮剂量为3.25 ± 2.12 mg。总REM计数（斯皮尔曼R= 0.57; P= 0.03）和平均REM计数（>= 0.54; P= 0.046）与奎替鲁肽剂量呈正相关。奎硫平和利培酮治疗的患者之间的睡眠质量指标没有差异。匹兹堡睡眠质量量表测量与任何睡眠脑电图测量或治疗组的药物剂量均无显著相关性，与先前的研究结果一致，1接受治疗的慢性精神分裂症患者睡眠维持减少，睡眠潜伏期和清醒时间增加。与从未接受过治疗的精神分裂症受试者相比，他们的慢波睡眠和快速眼动睡眠减少也更明显，但2期百分比更高。因此，在慢性精神分裂症中，睡眠可能更肤浅;这可能会降低睡眠质量，因为睡眠深度和SWS总量已被发现与睡眠质量有关。12
(Wilks Lambda= 0.59; F15= 3.14; P< 0.0000) across the 3 patient groups. Individual analyses of variance revealed that by comparison to the NNS group, both the QS and RS groups had more time in bed, reduced sleep maintenance, prolonged sleep latency, and increased wake time but no difference in total time spent asleep. The REM latency was marginally increased, and REM percentage decreased in the QS and RS groups compared with that in the NNS group. Stage 2 sleep was significantly increased, whereas SWS was decreased in both QS and RS groups. The QS and RS groups did not differ in any visually scored sleep measure (data not shown). Individual ANCOVAs revealed interesting group differences in both REM and delta counts (total and average)(Table 1). Post hoc comparisons revealed that average REM counts were highly significantly elevated in the QS group compared with those in the NNS, but the RS group did not differ from the NNS group. We also examined if a dose-effect relationship exists between medication dose and the REM counts. The mean quetiapine dose was 313.33 T 228.71 mg, and the mean risperidone dose was 3.25 T 2.12 mg. Total (Spearman R= 0.57; P= 0.03) and average REM counts (>= 0.54; P= 0.046) correlated positively with quetiapine dose. None of the sleep quality measures differed between the quetiapine-and risperidone-treated patients. Pittsburgh Sleep Quality Inventory measures did not significantly correlate with any of the sleep electroencephalogram measures or medication dose in either treated group.Consistent with prior findings, 1 treated patients with chronic schizophrenia had reduced sleep maintenance and increases in sleep latency and awake time. They also had more prominent SWS and REM sleep reductions but more stage 2 percentage compared with never-treated schizophrenia subjects. Thus, in chronic schizophrenia, sleep may be more superficial; this may reduce sleep quality because sleep depth and the total SWS amounts have been found to be related to sleep quality. 12
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影响因子：
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作者：
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DOI：
--
发表时间：
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影响因子：
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DOI：
10.1073/pnas.78.7.4349
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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